CORE B - Abstract Virtually all existing pregnancy outcome studies for women with psychiatric illness have suffered from one of two critical shortcomings: 1) a reliance on retrospective reports, even when subjects are prospectively identified, to document the exposures and course of illness during gestation, and 2) a myopic focus on the effects of fetal exposure to psychotropic medication with minimal effort to control for the effects of psychiatric illness/stress and vice versa. The principal goal of Core B, the Human Subjects Core, is to overcome these limitations and provide the Center's fetal and infant outcome projects with a cohort of biological mothers and fathers of babies with wellcharacterized pregnancies with respect to stress, psychiatric illness, psychotropic medication, and other concomitant exposures including tobacco, over-the-counter remedies, etc. In summary, the product of Core B will be prospectively collected longitudinal indices of fetal/infant exposure to both maternal psychiatric illness and the treatments for illness that will in turn will serve as the independent, i.e., exposure, variables in the Center's clinical projects.
The specific aims of the Human Subjects Core are: 1) to extend our group's extensive experience in prospective documentation of the perinatal course of mood and anxiety disorders by implementing a naturalistic observational study of a large sample of pregnant women with and without a history of depression and/or anxiety disorders;2) to derive an accurate phenotypic characterization of each participant using a battery of diagnosis specific assessment instruments, 3) to facilitate access to biological samples from this cohort that will be analyzed in other Center cores and projects, and 4) to maintain an electronic repository for the demographic, psychometric, and biological data collected in the Core that can be readily exported for statistical analysis in the Center's projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH077928-03
Application #
7931870
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2009-08-01
Project End
2012-07-31
Budget Start
2009-08-01
Budget End
2010-07-31
Support Year
3
Fiscal Year
2009
Total Cost
$340,362
Indirect Cost
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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House, Samuel J; Tripathi, Shanti P; Knight, Bettina T et al. (2016) Obsessive-compulsive disorder in pregnancy and the postpartum period: course of illness and obstetrical outcome. Arch Womens Ment Health 19:3-10
Knight, Anna K; Craig, Jeffrey M; Theda, Christiane et al. (2016) An epigenetic clock for gestational age at birth based on blood methylation data. Genome Biol 17:206
Johnson, Katrina C; Smith, Alicia K; Stowe, Zachary N et al. (2016) Preschool outcomes following prenatal serotonin reuptake inhibitor exposure: differences in language and behavior, but not cognitive function. J Clin Psychiatry 77:e176-82
Ehrlich, David E; Neigh, Gretchen N; Bourke, Chase H et al. (2015) Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. Neuropharmacology 97:251-8
Postpartum Depression: Action Towards Causes and Treatment (PACT) Consortium (2015) Heterogeneity of postpartum depression: a latent class analysis. Lancet Psychiatry 2:59-67

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