Response variability is a fact of the brain. There can be dramatic differences in the responses ofany given neuron, to any given stimulus, at different moments in time. Different neurons in anycortical area contributing to the representation of any given stimulus or action commonly havesubstantially different responses. Variations in distributed local, system, and brain-wide responsesrepresenting any given stimulus in any given behavioral context can differ radically in differentindividuals. At the same time, the brain operates with the maintenance of perceptual constancy,cognitive reliability, and learned-behavior stereotypy. How do we account for the robust behavioralrepresentations of inputs and actions in the face of the marked response variability of theirneurological representations? This project will address 3 issues. First, it will determine the basicconsequences, for neurological response variability, of exposing neonatal rats across the criticalperiod with stereotyped vs naturally variable complex acoustic (speech-like) stimulus sets. Second,it will determine whether or not and how systematically varying the modulatory inputs enablinglearning-induced plasticity in adult brains contribute to distributed neuronal response variability andcoordination, and to behavioral response variability, in an auditory stimulus recognition task. Third,it will investigate the relationships between variation in neuronal responses in the primary auditorycortex (A-1) and in 'secondary' auditory cortical fields (PVAF; AAF; PAF;PPVAF), as a function ofstimulus repertoire complexity, in trained adult rats. The long-term goal of this project is todetermine how a neurological strategy of learning-driven abstraction and coordination can lead tonew insights into how we can potentially revise learning strategies to improve their effectivenessand reliability for neuro-behaviorally impaired human populations.
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| Chaisanguanthum, Kris S; Shen, Helen H; Sabes, Philip N (2014) Motor variability arises from a slow random walk in neural state. J Neurosci 34:12071-80 |
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