The main goal of this core is to provide the brain mapping expertise, both with regards to magneticresonance imaging and electrophysiological techniques, for use in Projects 1,2,3, and 5. This core willenable examination at both the neurobiological and psychological levels of analysis, explicitly addressing acenter goal of linking levels of analysis in our understanding of executive function. The core will provide for:a)the quality control, storage, analysis and archiving of MRI and ERP data;b) documentation of data structures and processing proceduresc) the incorporating of new analytic tools into the data analysis pathd) support staff for running brain mapping experimentse) training in these research methods as well as the creation of materials for training purposesf) preparation of data for data sharing, and other associated functionsWith regards to neuroimaging, this core will also provide:a) installation of system upgrades and improvements to hardwareb) the development of new acquisition and pre-processing methods, especially those that deal withsusceptibility artifact and low signal-to-noise ratio.c) the application of new statistical methods to data analysisd) clinical expertise should any structural abnormalities be observed in participantsWith regards to electrophysiological techniques, this core will also provide:a) standardization of data collection across high-density array recording systemb) expand methods and approaches for the integration of data from fMRI and ERP experiments that havebeen designed in parallel. More specifically it will examine various ways in which fMRI data can be used toseed dipole sources for ERP data, and the ways in which these sources can be disentangled.Understanding the relationship between neurobiological markers and psychological functioning has largeimplications for mental health. It provides a potential avenue for new procedures for diagnosis andassessment for the efficacy of treatment for executive dysfunction associated with psychiatric disorders.
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