GAD and related anxiety disorders in youth are chronic and highly impairing. Cognitive-behavioral therapy(CBT), and other active forms of psychotherapy (e.g. education, support), are associated with reductions inanxiety (Barrett et al 1996; Kendall et al 1997; Last et al 1998; Silverman et al 1999); however,approximately 44% of anxious children treated with CBT do not improve (James et al 2005). Understandingpredictors and correlates of treatment response in child anxiety will allow us to: (1) target treatments tochildren most likely to benefit, (2) refine treatments by focusing on components shown to be associated withtreatment response, and (3) develop new treatments tailored to CBT non-responders. We propose that childanxiety disorders, as exemplified by GAD (Rapee, 2002), are associated with a 'vigilance-avoidance' patterncharacterized by problems in monitoring and evaluating emotional information and modifying emotionalreactions. This pattern can be reinforced by controlling and critical parenting behaviors, parentalpsychopathology, and negative interactions with peers. CBT treatments for child anxiety target disruptions inemotion regulation by teaching children skills for identifying and managing negative emotion and providingopportunities to practice these skills during exposures. These skills are then presumed to generalize to socialinteractions in daily life settings outside the clinic, including interactions with parents and peers. Althoughimprovements in affective functioning in the social context are believed to play a role in anxious children'spositive response to CBT, research has not yet clearly demonstrated links between children's or parents'affective behaviors and their response to treatment. We will examine how children's emotion regulation in thesocial context and their relationships with parents and peers (1) predict initial and long-term response to CBTtreatment (individually and compared to an active comparison Child Centered treatment) and (2) changeacross the course of treatment. We will rely on two ecologically valid methods for assessing affectivebehaviors in naturalistic contexts: (a) Behavioral Observation and (b) Ecological Momentary Assessment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH080215-01A1
Application #
7484045
Study Section
Special Emphasis Panel (ZMH1-ERB-L (01))
Project Start
2008-06-01
Project End
2013-05-31
Budget Start
2008-06-01
Budget End
2009-05-31
Support Year
1
Fiscal Year
2008
Total Cost
$224,853
Indirect Cost
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Ricketts, Emily J; Price, Rebecca B; Siegle, Greg J et al. (2018) Vigilant attention to threat, sleep patterns, and anxiety in peripubertal youth. J Child Psychol Psychiatry 59:1309-1322
Silk, Jennifer S; Tan, Patricia Z; Ladouceur, Cecile D et al. (2018) A Randomized Clinical Trial Comparing Individual Cognitive Behavioral Therapy and Child-Centered Therapy for Child Anxiety Disorders. J Clin Child Adolesc Psychol 47:542-554
Stone, Lindsey B; Mennies, Rebekah J; Waller, Jennifer M et al. (2018) Help me Feel Better! Ecological Momentary Assessment of Anxious Youths' Emotion Regulation with Parents and Peers. J Abnorm Child Psychol :
Ladouceur, Cecile D; Tan, Patricia Z; Sharma, Vinod et al. (2018) Error-related brain activity in pediatric anxiety disorders remains elevated following individual therapy: a randomized clinical trial. J Child Psychol Psychiatry 59:1152-1161
McMakin, Dana L; Ricketts, Emily J; Forbes, Erika E et al. (2018) Anxiety Treatment and Targeted Sleep Enhancement to Address Sleep Disturbance in Pre/Early Adolescents with Anxiety. J Clin Child Adolesc Psychol :1-14
Wallace, Meredith L; McMakin, Dana L; Tan, Patricia Z et al. (2017) The role of day-to-day emotions, sleep, and social interactions in pediatric anxiety treatment. Behav Res Ther 90:87-95
Morgan, Judith K; Lee, Grace E; Wright, Aidan G C et al. (2017) Altered Positive Affect in Clinically Anxious Youth: the Role of Social Context and Anxiety Subtype. J Abnorm Child Psychol 45:1461-1472
Price, Rebecca B; Allen, Kristy Benoit; Silk, Jennifer S et al. (2016) Vigilance in the laboratory predicts avoidance in the real world: A dimensional analysis of neural, behavioral, and ecological momentary data in anxious youth. Dev Cogn Neurosci 19:128-136
Oppenheimer, Caroline W; Ladouceur, Cecile D; Waller, Jennifer M et al. (2016) Emotion Socialization in Anxious Youth: Parenting Buffers Emotional Reactivity to Peer Negative Events. J Abnorm Child Psychol 44:1267-78
Price, Rebecca B; Rosen, Dana; Siegle, Greg J et al. (2016) From anxious youth to depressed adolescents: Prospective prediction of 2-year depression symptoms via attentional bias measures. J Abnorm Psychol 125:267-278

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