The primary goals of this project are to examine the short and long-term effects of improving sleep as an important component of treating anxiety disorders in youth. These goals build upon four lines of evidence regarding sleep and emotion regulation in adolescence: 1) Developmental changes in sleep, circadian, and affective systems at puberty create increased vulnerabilities for both sleep and emotional problems (and their interactions) in ways that lead to high rates of sleep difficulties in adolescence. 2) Youth with Generalized Anxiety Disorder are particularly prone to sleep problems because of increased vigilance and inclinations to worry and ruminate at bedtime;3) Sleep loss can interfere with affect regulation and distress tolerance, and thus, sleep difficulties create added burdens in the domains of affective and social functioning. 4) Insomnia and chronic sleep disturbance are significant risk factors for the development of depression and other adverse health outcomes. Taken together, these four lines of evidence raise compelling questions regarding the opportunities for early intervention to improve and enhance sleep in youth with anxiety. Project 2 addresses these questions by: (a) assessing sleep changes during CBT for anxiety to examine whether sleep improvements may partially mediate some positive effects of CBT;(b) offering a six-week sleep intervention to those children who continue to show sleep difficulties after CBT (c) testing this sleep intervention by randomizing 2/3 to receive the multi-component sleep intervention and 1/3 to receive a comparison supportive treatment;and (d) assessing whether improving sleep will further enhance affective, clinical, and social functioning. This project addresses a set of issues of considerable clinical relevance in treating anxiety disorders. It also examines early adolescence as a key time in development for sleep intervention in ways that could inform a prevention strategy for depression. More generally, this project addresses issues of great concern to public health and social policy regarding the consequences of insufficient sleep in youth?not only its effects on cognitive, emotional, behavioral, and academic function, but also a broader range of health problems where sleep has been implicated, including the development of affective disorders, alcohol, nicotine, and other substance use, accidents, and obesity and metabolic syndrome.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH080215-05
Application #
8379153
Study Section
Special Emphasis Panel (ZMH1-ERB-L)
Project Start
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$162,291
Indirect Cost
$49,411
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Ricketts, Emily J; Price, Rebecca B; Siegle, Greg J et al. (2018) Vigilant attention to threat, sleep patterns, and anxiety in peripubertal youth. J Child Psychol Psychiatry 59:1309-1322
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Morgan, Judith K; Lee, Grace E; Wright, Aidan G C et al. (2017) Altered Positive Affect in Clinically Anxious Youth: the Role of Social Context and Anxiety Subtype. J Abnorm Child Psychol 45:1461-1472
Price, Rebecca B; Allen, Kristy Benoit; Silk, Jennifer S et al. (2016) Vigilance in the laboratory predicts avoidance in the real world: A dimensional analysis of neural, behavioral, and ecological momentary data in anxious youth. Dev Cogn Neurosci 19:128-136
Oppenheimer, Caroline W; Ladouceur, Cecile D; Waller, Jennifer M et al. (2016) Emotion Socialization in Anxious Youth: Parenting Buffers Emotional Reactivity to Peer Negative Events. J Abnorm Child Psychol 44:1267-78
Price, Rebecca B; Rosen, Dana; Siegle, Greg J et al. (2016) From anxious youth to depressed adolescents: Prospective prediction of 2-year depression symptoms via attentional bias measures. J Abnorm Psychol 125:267-278

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