Abstract

This application requests five years of support to establish a Project on """"""""Functional Neuroanatomy of Neurocognitive Deterioration in Schizophrenia"""""""". This project, utilizing neuropsychological and neuroimaging measures is a part of an NIMH Center for Intervention Development and Applied Research (""""""""CIDAR""""""""), entitled 'Vulnerability to Progression in Schizophrenia"""""""". Utilizing our expertise in neuropsychology, cognitive neuroscience and structural neuroimaging, we expect to map the functional neuroanatomy of neurocognitive deterioration in the prodromal period and develop biomarkers for predicting conversion to psychosis, and further deterioration. Our focus on executive control reflects the belief that this is the central mechanism associated with growing cortical gray matter loss over time in schizophrenia. We will perform functional and structural neuroimaging on 75 persons considered to be """"""""prodromal"""""""" for schizophrenia (24 of whom are expected to convert) and 75 matched controls. Each subject will be assessed at baseline and one year follow-up. We believe that in-depth understanding of the functional neuroanatomy of the prodromal period is a necessary precondition for better treatment, and possible prevention of the illness.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH080272-04
Application #
8136026
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2010-09-01
Project End
2012-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
4
Fiscal Year
2010
Total Cost
$274,974
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Seitz, Johanna; Rathi, Yogesh; Lyall, Amanda et al. (2018) Alteration of gray matter microstructure in schizophrenia. Brain Imaging Behav 12:54-63
Kline, Emily; Hendel, Victoria; Friedman-Yakoobian, Michelle et al. (2018) A comparison of neurocognition and functioning in first episode psychosis populations: do research samples reflect the real world? Soc Psychiatry Psychiatr Epidemiol :
Hampton, Joya N; Trotman, Hanan D; Addington, Jean et al. (2018) The relation of atypical antipsychotic use and stress with weight in individuals at clinical high risk for psychosis. Stress Health 34:591-600
Saito, Yukiko; Kubicki, Marek; Koerte, Inga et al. (2018) Impaired white matter connectivity between regions containing mirror neurons, and relationship to negative symptoms and social cognition, in patients with first-episode schizophrenia. Brain Imaging Behav 12:229-237
Woodberry, Kristen A; Seidman, Larry J; Bryant, Caitlin et al. (2018) Treatment Precedes Positive Symptoms in North American Adolescent and Young Adult Clinical High Risk Cohort. J Clin Child Adolesc Psychol 47:69-78
Ohtani, Toshiyuki; Del Re, Elisabetta; Levitt, James J et al. (2018) Progressive symptom-associated prefrontal volume loss occurs in first-episode schizophrenia but not in affective psychosis. Brain Struct Funct 223:2879-2892
Konishi, Jun; Del Re, Elisabetta C; Bouix, Sylvain et al. (2018) Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study. Brain Imaging Behav 12:974-988
Stowkowy, Jacqueline; Liu, Lu; Cadenhead, Kristin S et al. (2018) Exploration of clinical high-risk dropouts. Schizophr Res 195:579-580
Hamoda, Hesham M; Makhlouf, A T; Fitzsimmons, J et al. (2018) Abnormalities in thalamo-cortical connections in patients with first-episode schizophrenia: a two-tensor tractography study. Brain Imaging Behav :
Chung, Yoonho; Haut, Kristen M; He, George et al. (2017) Ventricular enlargement and progressive reduction of cortical gray matter are linked in prodromal youth who develop psychosis. Schizophr Res 189:169-174

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