Project 3 seeks to understand the longitudinal pattern of behavioral problems in twin children by following up a sample previously systematically ascertained from birth records. The project uses genetic latent class analysis applied to 3-occasion, longitudinal data (age 7-8 years, 12-13 years, and 15-16 years) as a foundation for understanding temperamental and family risk factors, as well as to provide a sample for studying neural correlates of adolescent anxiety in Project 4. We predict that the child's standing on a profile of seven dimensions (depressed, socially anxious, worried/obsessive, inattentive, impulsive, hyperactive, defiant/aggressive/callous) assessed with multiple methods will reveal heterogeneity within existing DSM-IV diagnostic categories and commonality among subgroups of children with different DSM-IV diagnoses. Several risk factors will be examined within the context of latent growth curve analysis, including basal and reactive cortisol patterns studied longitudinally, allelic variants of 8 genes, family stress and observed family interaction patterns, pregnancy and birth complications, and childhood temperament. Operationally, the project involves conducting telephone interviews of both twins and their mothers for a sample over 1,200 twins and their mothers, extensive statistical analyses of the longitudinal data, and a laboratory-based assessment of a subsample who qualify for a diagnosis of anxiety disorder or depression. The laboratory-based assessment battery will include a structured psychiatric interview, cognitive/affective assessments (reaction time and other performance-based measures), and the Trier Social Stress Test as protocol to activate the HPA axis. Results should improve understanding of (1) nosology of childhood anxiety problems;(2) how risk factors act over a substantial period of childhood and adolescence;and (3) cognitive and other processes that may form the substrate of anxious behavior.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH084051-03
Application #
8076862
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2010-06-01
Project End
2013-05-31
Budget Start
2010-06-01
Budget End
2011-05-31
Support Year
3
Fiscal Year
2010
Total Cost
$283,101
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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