The Conte Bioinformatics and Biostatistics Core has a strong history of close interaction with Conte investigators including the current Center grant funding period, as evidenced by joint publications and the joint development of novel computational algorithms and user-friendly software applications. The Core will continue to sustain the increasing bioinformatics and biostatistics needs of the supported projects and pilot activities. As proposed in the projects, global characterization of epigenomic, transcriptomic, and proteomic changes in response to 5-HT signaling across the life-span will eventually help elucidate the complex molecular mechanisms underlying multiple brain disorders. However, we face tremendous challenges in processing, analyzing, integrating, and interpreting large and heterogeneous datasets generated by multi-level, data rich approaches. A major goal of the Core is to provide computational support to expedite scientific discoveries across multidimensional data sets. We achieve the goal by providing support for data storage, data sharing, and data mining. We utilize a formal data categorization scheme with four data levels that facilitate the location and exchange of data of interest. We provide support for experimental design and statistical data analysis, ensuring that experiments are well planned and powered and pursued with the standards of good statistical design. We perform data analysis using robust, modern statistical models as well as with exploratory graphical techniques. The Core provides support for pathway and network-based data integration and analysis that will be critical for the proposed genome- and transcriptome-wide characterizations of changes induced by developmental 5-HT signaling. The Core plays a critical role in facilitating the integration of data sets generated by individual projects, which can be best achieved through pathway and network-based data analysis and takes advantage of pathway-level statistical analysis and visualization.

Public Health Relevance

The Bioinformatics and Biostatistics Core of the Vanderbilt Conte Center provides expert oversight and creation of approaches to facilitate the integrative and quantitative analysis of large, multidimensional data sets within a framework where tools and analyses can be made readily accessible by the research community at large. The Core is the central node in the Conte Center's network of senior and junior investigators, major and pilot project leaders, where data streams are routed productively to insure effective awareness of modern analytical practices and appropriate statistical methodologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH096972-02
Application #
8535211
Study Section
Special Emphasis Panel (ZMH1-ERB-S)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
2
Fiscal Year
2013
Total Cost
$91,713
Indirect Cost
$32,923
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Stewart, Adele; Davis, Gwynne L; Gresch, Paul J et al. (2018) Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. Neuropsychopharmacology :
Mayer, Felix P; Schmid, Diethart; Owens, W Anthony et al. (2018) An unsuspected role for organic cation transporter 3 in the actions of amphetamine. Neuropsychopharmacology 43:2408-2417
Robson, Matthew J; Quinlan, Meagan A; Margolis, Kara Gross et al. (2018) p38? MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A 115:E10245-E10254
Brindley, Rebecca L; Bauer, Mary Beth; Walker, L Anne et al. (2018) Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter. Pharmacol Res :
Knoll, A T; Jiang, K; Levitt, P (2018) Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits. Genes Brain Behav 17:e12431
Deneris, Evan; Gaspar, Patricia (2018) Serotonin neuron development: shaping molecular and structural identities. Wiley Interdiscip Rev Dev Biol 7:
Ritter, K Elaine; Wang, Zunyi; Vezina, Chad M et al. (2017) Serotonin Receptor 5-HT3A Affects Development of Bladder Innervation and Urinary Bladder Function. Front Neurosci 11:690
Kast, Ryan J; Wu, Hsiao-Huei; Williams, Piper et al. (2017) Specific Connectivity and Unique Molecular Identity of MET Receptor Tyrosine Kinase Expressing Serotonergic Neurons in the Caudal Dorsal Raphe Nuclei. ACS Chem Neurosci 8:1053-1064
O'Neil, Richard T; Wang, Xiaojing; Morabito, Michael V et al. (2017) Comparative analysis of A-to-I editing in human and non-human primate brains reveals conserved patterns and context-dependent regulation of RNA editing. Mol Brain 10:11
Sharif, N F; Korade, Z; Porter, N A et al. (2017) Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome. Genes Brain Behav 16:619-626

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