The Conte Bioinformatics and Biostatistics Core has a strong history of close interaction with Conte investigators including the current Center grant funding period, as evidenced by joint publications and the joint development of novel computational algorithms and user-friendly software applications. The Core will continue to sustain the increasing bioinformatics and biostatistics needs of the supported projects and pilot activities. As proposed in the projects, global characterization of epigenomic, transcriptomic, and proteomic changes in response to 5-HT signaling across the life-span will eventually help elucidate the complex molecular mechanisms underlying multiple brain disorders. However, we face tremendous challenges in processing, analyzing, integrating, and interpreting large and heterogeneous datasets generated by multi-level, data rich approaches. A major goal of the Core is to provide computational support to expedite scientific discoveries across multidimensional data sets. We achieve the goal by providing support for data storage, data sharing, and data mining. We utilize a formal data categorization scheme with four data levels that facilitate the location and exchange of data of interest. We provide support for experimental design and statistical data analysis, ensuring that experiments are well planned and powered and pursued with the standards of good statistical design. We perform data analysis using robust, modern statistical models as well as with exploratory graphical techniques. The Core provides support for pathway and network-based data integration and analysis that will be critical for the proposed genome- and transcriptome-wide characterizations of changes induced by developmental 5-HT signaling. The Core plays a critical role in facilitating the integration of data sets generated by individual projects, which can be best achieved through pathway and network-based data analysis and takes advantage of pathway-level statistical analysis and visualization.

Public Health Relevance

The Bioinformatics and Biostatistics Core of the Vanderbilt Conte Center provides expert oversight and creation of approaches to facilitate the integrative and quantitative analysis of large, multidimensional data sets within a framework where tools and analyses can be made readily accessible by the research community at large. The Core is the central node in the Conte Center's network of senior and junior investigators, major and pilot project leaders, where data streams are routed productively to insure effective awareness of modern analytical practices and appropriate statistical methodologies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
4P50MH096972-05
Application #
9097795
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
5
Fiscal Year
2016
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37240
Stewart, Adele; Davis, Gwynne L; Gresch, Paul J et al. (2018) Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice. Neuropsychopharmacology :
Mayer, Felix P; Schmid, Diethart; Owens, W Anthony et al. (2018) An unsuspected role for organic cation transporter 3 in the actions of amphetamine. Neuropsychopharmacology 43:2408-2417
Robson, Matthew J; Quinlan, Meagan A; Margolis, Kara Gross et al. (2018) p38? MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A 115:E10245-E10254
Brindley, Rebecca L; Bauer, Mary Beth; Walker, L Anne et al. (2018) Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter. Pharmacol Res :
Knoll, A T; Jiang, K; Levitt, P (2018) Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits. Genes Brain Behav 17:e12431
Deneris, Evan; Gaspar, Patricia (2018) Serotonin neuron development: shaping molecular and structural identities. Wiley Interdiscip Rev Dev Biol 7:
Van Segbroeck, Maarten; Knoll, Allison T; Levitt, Pat et al. (2017) MUPET-Mouse Ultrasonic Profile ExTraction: A Signal Processing Tool for Rapid and Unsupervised Analysis of Ultrasonic Vocalizations. Neuron 94:465-485.e5
Siemann, J K; Muller, C L; Forsberg, C G et al. (2017) An autism-associated serotonin transporter variant disrupts multisensory processing. Transl Psychiatry 7:e1067
Spencer, William C; Deneris, Evan S (2017) Regulatory Mechanisms Controlling Maturation of Serotonin Neuron Identity and Function. Front Cell Neurosci 11:215
Simmler, Linda D; Anacker, Allison M J; Levin, Michael H et al. (2017) Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine. Br J Pharmacol 174:2716-2738

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