Abstract

Based on the central hypothesis of all research conducted in this Conte Center, Project 2 will establish a two developmentally-dissociable insult (?double-hit?) model to study the effects of timed intervention with a kynurenine aminotransferase (KAT) II inhibitor. This project will bridge knowledge from Project 1 (mice) to Projects 3 and 4 (humans) through an intermediary translational animal model - miniature pigs (Sus scrofa domestica). Miniature pigs have large gyrencephalic brains and a developmental trajectory similar to humans, providing the opportunity for human-equivalent invasive neuroscience techniques and neuroimaging brain assessments. Project 2 will mirror the experiments in Project 1 by mapping the effects of chronic elevations in kynurenic acid (KYNA) during the second trimester of pregnancy (1st hit) and in adolescence (2nd hit) using neuroimaging and electrophysiology protocols identical to those used in Projects 3 and 4. The assessment protocols, analytical workflows and multimodal brain atlases developed in this project will be disseminated in an effort to accelerate the use of pig models in neuropsychiatric research. 1

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH103222-07
Application #
10016395
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2014-05-09
Project End
2024-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
7
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
DUNS #
188435911
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Albrecht, Matthew A; Vaughn, Chloe N; Erickson, Molly A et al. (2018) Time and frequency dependent changes in resting state EEG functional connectivity following lipopolysaccharide challenge in rats. PLoS One 13:e0206985
Du, Xiaoming; Hong, L Elliot (2018) Test-retest reliability of short-interval intracortical inhibition and intracortical facilitation in patients with schizophrenia. Psychiatry Res 267:575-581
Du, Xiaoming; Rowland, Laura M; Summerfelt, Ann et al. (2018) TMS evoked N100 reflects local GABA and glutamate balance. Brain Stimul 11:1071-1079
Du, Xiaoming; Rowland, Laura M; Summerfelt, Ann et al. (2018) Cerebellar-Stimulation Evoked Prefrontal Electrical Synchrony Is Modulated by GABA. Cerebellum :
Song, Chang; Clark, Sarah M; Vaughn, Chloe N et al. (2018) Quantitative Analysis of Kynurenine Aminotransferase II in the Adult Rat Brain Reveals High Expression in Proliferative Zones and Corpus Callosum. Neuroscience 369:1-14
Chiappelli, Joshua; Notarangelo, Francesca M; Pocivavsek, Ana et al. (2018) Influence of plasma cytokines on kynurenine and kynurenic acid in schizophrenia. Neuropsychopharmacology 43:1675-1680
van Erp, Theo G M; Walton, Esther; Hibar, Derrek P et al. (2018) Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biol Psychiatry 84:644-654
Pocivavsek, Ana; Rowland, Laura M (2018) Basic Neuroscience Illuminates Causal Relationship Between Sleep and Memory: Translating to Schizophrenia. Schizophr Bull 44:7-14
Hahn, Britta; Reneski, Carolyn H; Pocivavsek, Ana et al. (2018) Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood. Psychopharmacology (Berl) 235:651-661
Kelly, Deanna L; Li, Xin; Kilday, Catherine et al. (2018) Increased circulating regulatory T cells in medicated people with schizophrenia. Psychiatry Res 269:517-523

Showing the most recent 10 out of 78 publications