Abstract

This program is a multidisciplinary approach to the problems of spinal cord injury (SCI). Included are: An epidemiological study of spinal cord injury in Connecticut with delineation of incidence, cause, evaluation of treatment, cost comparison of treatment in an organized SCI center and community hospitals in Connecticut, and determination of when stability of neurological function occurs; studies of animal models of spinal cord injury, evaluating various treatment modalities, effects of trauma on spinal cord blood flow and metabolism, determination of spinal column stability including computer models of primate spinal column; post-traumatic alteration in blood-spinal cord barrier; the effect of biogenic amines on the resulting neurological dysfunction and ultrastructural analysis of the effect of impact trauma, the development and study of a model system in the Larvil Lamprey (Petromyzon Marinus) for study of regeneration in the central nervous system, a study of the formation of peripheral neuroma and the factors controlling its size, and study of the olfactory bulb re-establishment of central synaptic connection following injury.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS010174-14
Application #
3107578
Study Section
Neurological Disorders Program Project Review A Committee (NSPA)
Project Start
1978-09-01
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
14
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code

  Publications

Radtke, Christine; Akiyama, Yukinori; Brokaw, Jane et al. (2004) Remyelination of the nonhuman primate spinal cord by transplantation of H-transferase transgenic adult pig olfactory ensheathing cells. FASEB J 18:335-7
Liu, Chang-Ning; Devor, Marshall; Waxman, Stephen G et al. (2002) Subthreshold oscillations induced by spinal nerve injury in dissociated muscle and cutaneous afferents of mouse DRG. J Neurophysiol 87:2009-17
Akiyama, Yukinori; Radtke, Christine; Honmou, Osamu et al. (2002) Remyelination of the spinal cord following intravenous delivery of bone marrow cells. Glia 39:229-36
Akiyama, Yukinori; Radtke, Christine; Kocsis, Jeffery D (2002) Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J Neurosci 22:6623-30
Lankford, Karen L; Imaizumi, Toshio; Honmou, Osamu et al. (2002) A quantitative morphometric analysis of rat spinal cord remyelination following transplantation of allogenic Schwann cells. J Comp Neurol 443:259-74
Sasaki, M; Honmou, O; Akiyama, Y et al. (2001) Transplantation of an acutely isolated bone marrow fraction repairs demyelinated adult rat spinal cord axons. Glia 35:26-34
Kohama, I; Lankford, K L; Preiningerova, J et al. (2001) Transplantation of cryopreserved adult human Schwann cells enhances axonal conduction in demyelinated spinal cord. J Neurosci 21:944-50
Yan, H; Nie, X; Kocsis, J D (2001) Hepatocyte growth factor is a mitogen for olfactory ensheathing cells. J Neurosci Res 66:698-704
Everill, B; Cummins, T R; Waxman, S G et al. (2001) Sodium currents of large (Abeta-type) adult cutaneous afferent dorsal root ganglion neurons display rapid recovery from inactivation before and after axotomy. Neuroscience 106:161-9
Imaizumi, T; Lankford, K L; Kocsis, J D (2000) Transplantation of olfactory ensheathing cells or Schwann cells restores rapid and secure conduction across the transected spinal cord. Brain Res 854:70-8

Showing the most recent 10 out of 34 publications