Seizures and epilepsy are among the most common neurologic disorders in the elderly. Seizure can occur in many ways, including uncontrollable tonic and/or clonic jerks and/or a momentary loss of consciousness and/or altered mental state. The etiology of the seizure may be recognized (symptomatic) or unrecognized (idiopathic/cryogenic), and the initial event may occur at any stage of life. Classification schemes for epileptic seizures according to clinical and EEG features and recognized syndromes have been proposed that allows comparison of results across studies. To date, however, few studies have been focused on non-Caucasians or on the elderly. The goal of this population-based study is to determine the prevalence and incidence of seizures and epilepsy among older African-Americans and Caucasians participating in the ARIC (Atherosclerosis Risk in Communities) study. We propose to analyze data collected as part of the ARIC study, a prospective cohort study consisting of 15,792 free-living residents from Forsyth County, NC, Jackson, MS, Minneapolis/St. Paul, MN, and Washington County, MD. The ARIC baseline examination was conducted between 1987-1989, during which trained interviewers collected information on medical history and risk factors, blood pressure measurements, pulmonary function studies, and other associated measurements. Data from the second ARIC visit (1990- 1992) have similarly been collected. ARIC visit three data are currently being collected (1993-1995), and ARIC visit four data will be collected during the period of this study (1996-1999). Using these data, we propose to (1) Determine the frequency of seizures by estimating the prevalence in this populations bey ethnicity and describing the prevalence within subgroups defined by age, sex, and location; (2) Compare the prevalence with respect to selected epilepsy and VCD risk factors; and (3) Determine the incidence of seizures among this population of African-American and Caucasians. Age- adjusted incidence rates by sex and by ethnic group will be estimated and we will compare the cumulative incidence rates in ARIC with that in Rochester, MN. This study focuses on two understudied groups with respect to seizures -- the elderly and African-Americans. Studies of the prevalence and incidence of seizures in the ARIC data, especially when coupled with the extensive, already collected, CVD risk factor data, can provide data of importance to understanding the etiology of seizures and epilepsy, and complement the medical information obtained in other projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS016308-18
Application #
6112140
Study Section
Project Start
1998-06-01
Project End
1999-05-31
Budget Start
Budget End
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Conway, Jeannine M; Eberly, Lynn E; Collins, Joseph F et al. (2017) Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy. Pharmacotherapy 37:1197-1203
Polepally, Akshanth R; Remmel, Rory P; Brundage, Richard C et al. (2015) Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology. J Clin Pharmacol 55:1101-8
Patel, Sima I; Birnbaum, Angela K; Cloyd, James C et al. (2015) Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy. CNS Drugs 29:1009-22
Conway, Jeannine M; Birnbaum, Angela K; Leppik, Ilo E et al. (2014) Safety of an intravenous formulation of lamotrigine. Seizure 23:390-2
Ghodke-Puranik, Yogita; Thorn, Caroline F; Lamba, Jatinder K et al. (2013) Valproic acid pathway: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics 23:236-41
Ahmed, Ghada F; Brundage, Richard C; Marino, Susan E et al. (2013) Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy. J Clin Pharmacol 53:276-84
Puranik, Yogita Ghodke; Birnbaum, Angela K; Marino, Susan E et al. (2013) Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy. Pharmacogenomics 14:35-45
Conway, Jeannine M; Birnbaum, Angela K; Marino, Susan E et al. (2012) A sensitive capillary GC-MS method for analysis of topiramate from plasma obtained from single-dose studies. Biomed Chromatogr 26:1071-6
Punyawudho, Baralee; Ramsay, Eugene R; Brundage, Richard C et al. (2012) Population pharmacokinetics of carbamazepine in elderly patients. Ther Drug Monit 34:176-81
Marino, S E; Birnbaum, A K; Leppik, I E et al. (2012) Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex. Clin Pharmacol Ther 91:483-8

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