The purpose of this multi-disciplinary Center is to explore the neural bases of language and cognitive development from 7-18 years of age, combining cross-sectional and longitudinal behavioral methods with neural imaging (event-related brain potentials (ERP); functional magnetic resonance imaging (fMRI) to study normal and abnormal brain development, and the alternative forms of brain organization that can emerge under pathological conditions, and the alternative forms of brain organization that can emerge under pathological conditions. Project A focuses on children with Language Impairment (LI); it examines the cognitive and neural correlates of LI, and test competing hypotheses about the processing deficits that underlie this disorder. Project B follows children with focal lesions (FL) to one side of the brain, acquired pre- or perinatally (before 6 months of ages); it will provide behavioral, fMRI and ERP evidence regarding the alternative forms of organization the underlie plastic reorganization in the plastic reorganization in this population. Project C compares Williams Syndrome (WMS), a rare form of mental retardation in which language is especially vulnerable. Project D is new, and constitutes an extension of Project 2 to study children with lesions of later onset in childhood, children with bilateral pathology, and children with slowly evolving lesions due to tumor; the purpose of this project is to increase our understanding of developmental and neurological limits on plasticity. Project E is new, a groundbreaking series of studies using fMRI, including BOLD activation studies of language, spatial processing and spatial attention, as well as perfusion studies of vascular organization. Project F continues our ERP studies of language, spatial cognition and basic auditory-visual processing in all populations. Core A handles administration, data base management, tracking and statistical consultation.. Core B is responsible for recruitment of controls, and handles screening, diagnosis and induction of all populations. Core C is a new joint behavioral testing facility that handles language and behavioral testing (excluding ERP and fMRI) for all populations, including language transcription.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS022343-16
Application #
6321205
Study Section
Special Emphasis Panel (ZNS1-SRB-R (01))
Program Officer
Edwards, Emmeline
Project Start
1985-09-16
Project End
2006-07-31
Budget Start
2001-08-15
Budget End
2002-07-31
Support Year
16
Fiscal Year
2001
Total Cost
$1,505,117
Indirect Cost
Name
University of California San Diego
Department
Other Health Professions
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Ng, Rowena; Lai, Philip; Brown, Timothy T et al. (2018) Neuroanatomical correlates of emotion-processing in children with unilateral brain lesion: A preliminary study of limbic system organization. Soc Neurosci 13:688-700
Stiles, Joan (2017) Principles of brain development. Wiley Interdiscip Rev Cogn Sci 8:
Jernigan, Terry L; Stiles, Joan (2017) Construction of the human forebrain. Wiley Interdiscip Rev Cogn Sci 8:
Fan, Chun Chieh; Brown, Timothy T; Bartsch, Hauke et al. (2017) Williams syndrome-specific neuroanatomical profile and its associations with behavioral features. Neuroimage Clin 15:343-347
Ng, Rowena; Brown, Timothy T; Järvinen, Anna M et al. (2016) Structural integrity of the limbic-prefrontal connection: Neuropathological correlates of anxiety in Williams syndrome. Soc Neurosci 11:187-92
Ng, Rowena; Brown, Timothy T; Erhart, Matthew et al. (2016) Morphological differences in the mirror neuron system in Williams syndrome. Soc Neurosci 11:277-88
Lai, Philip T; Reilly, Judy S (2015) Language and affective facial expression in children with perinatal stroke. Brain Lang 147:85-95
Webb, Sara Jane; Bernier, Raphael; Henderson, Heather A et al. (2015) Guidelines and best practices for electrophysiological data collection, analysis and reporting in autism. J Autism Dev Disord 45:425-43
Yousefian, Omid; Ballantyne, Angela O; Doo, Alex et al. (2015) Clock drawing in children with perinatal stroke. Pediatr Neurol 52:592-8
Polse, Lara R; Reilly, Judy S (2015) Orthographic and semantic processing in young readers. J Res Read 38:47-72

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