Abstract

Project 4 will focus on defining autoimmune autonomic neuropathy (AAN) as an antibody-mediated disorder and willevaluate features of antibody-mediated autonomic failure that may be relevant to other dysautonomic syndromes. Studiesin this project will provide a direct translational component to the clinical studies of AAN in Project 1 (Dr. Phillip Low)and physiological and serological correlates to the clinical studies of orthostatic tachycardia syndrome (POTS) in Projects1 and 3 (Dr. Michael Joyner).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS032352-14
Application #
7640796
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2008-08-01
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
14
Fiscal Year
2008
Total Cost
$248,591
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Coon, Elizabeth A; Low, Phillip A (2017) Pure autonomic failure without alpha-synuclein pathology: an evolving understanding of a heterogeneous disease. Clin Auton Res 27:67-68
Limberg, Jacqueline K; Johnson, Blair D; Holbein, Walter W et al. (2016) Interindividual variability in the dose-specific effect of dopamine on carotid chemoreceptor sensitivity to hypoxia. J Appl Physiol (1985) 120:138-47
Figueroa, Juan J; Singer, Wolfgang; Sandroni, Paola et al. (2015) Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension. Arch Phys Med Rehabil 96:505-10
Limberg, Jacqueline K; Taylor, Jennifer L; Mozer, Michael T et al. (2015) Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia. Hypertension 65:1365-71
Wehrwein, Erica A; Limberg, Jacqueline K; Taylor, Jennifer L et al. (2015) Effect of bilateral carotid body resection on the counterregulatory response to hypoglycaemia in humans. Exp Physiol 100:69-78
Moffett, Kristin; Crosson, Bruce; Spence, Jeffrey S et al. (2015) Word-finding impairment in veterans of the 1991 Persian Gulf War. Brain Cogn 98:65-73
Limberg, Jacqueline K; Dube, Simmi; Kuijpers, Myrthe et al. (2015) Effect of hypoxia on heart rate variability and baroreflex sensitivity during hypoglycemia in type 1 diabetes mellitus. Clin Auton Res 25:243-50
Bharucha, Adil E; Kudva, Yogish; Basu, Ananda et al. (2015) Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes. Clin Gastroenterol Hepatol 13:466-476.e1
Piccione, Ezequiel A; Sletten, David M; Staff, Nathan P et al. (2015) Autonomic system and amyotrophic lateral sclerosis. Muscle Nerve 51:676-9
Limberg, Jacqueline K; Farni, Kathryn E; Taylor, Jennifer L et al. (2014) Autonomic control during acute hypoglycemia in type 1 diabetes mellitus. Clin Auton Res 24:275-83

Showing the most recent 10 out of 66 publications