Abstract

In this competitive renewal of the Autonomic Disorders PPG, we provide a highly integrated proposal wherethe individual projects and the cores are tightly interwoven. In this spirit, we have combined an integrateddescription of the PPG overview and the CORE in the following description.Abbreviations: AAN = autoimmune autonomic neuropathy; AChR = acetylcholine receptor; ASP = autonomicsymptom profile; BP = blood pressure; CAP = Clinical, Administrative and Physiology; CARL = ClinicalAutonomic Reflex Laboratory; CASS = composite autonomic severity score; COMPASS = compositeautonomic symptom score; DLB = dementia with Lewy bodies; EAAN = experimental autoimmune autonomicneuropathy; GCRC = general clinical research center; HUT = head-up tilt; LBNP = lower body negativepressure; MSA = multiple system atrophy; OH = orthostatic hypotension; PI = principal investigator; POTS =postural orthostatic tachycardia syndrome; PPG = Program Project; QSART = quantitative sudomotor axonreflextes

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS032352-14
Application #
7640799
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2008-08-01
Project End
2010-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
14
Fiscal Year
2008
Total Cost
$248,590
Indirect Cost

  Institution

Name
Mayo Clinic, Rochester
Department
Type
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

Coon, Elizabeth A; Low, Phillip A (2017) Pure autonomic failure without alpha-synuclein pathology: an evolving understanding of a heterogeneous disease. Clin Auton Res 27:67-68
Limberg, Jacqueline K; Johnson, Blair D; Holbein, Walter W et al. (2016) Interindividual variability in the dose-specific effect of dopamine on carotid chemoreceptor sensitivity to hypoxia. J Appl Physiol (1985) 120:138-47
Figueroa, Juan J; Singer, Wolfgang; Sandroni, Paola et al. (2015) Effects of patient-controlled abdominal compression on standing systolic blood pressure in adults with orthostatic hypotension. Arch Phys Med Rehabil 96:505-10
Limberg, Jacqueline K; Taylor, Jennifer L; Mozer, Michael T et al. (2015) Effect of bilateral carotid body resection on cardiac baroreflex control of blood pressure during hypoglycemia. Hypertension 65:1365-71
Wehrwein, Erica A; Limberg, Jacqueline K; Taylor, Jennifer L et al. (2015) Effect of bilateral carotid body resection on the counterregulatory response to hypoglycaemia in humans. Exp Physiol 100:69-78
Moffett, Kristin; Crosson, Bruce; Spence, Jeffrey S et al. (2015) Word-finding impairment in veterans of the 1991 Persian Gulf War. Brain Cogn 98:65-73
Limberg, Jacqueline K; Dube, Simmi; Kuijpers, Myrthe et al. (2015) Effect of hypoxia on heart rate variability and baroreflex sensitivity during hypoglycemia in type 1 diabetes mellitus. Clin Auton Res 25:243-50
Bharucha, Adil E; Kudva, Yogish; Basu, Ananda et al. (2015) Relationship between glycemic control and gastric emptying in poorly controlled type 2 diabetes. Clin Gastroenterol Hepatol 13:466-476.e1
Piccione, Ezequiel A; Sletten, David M; Staff, Nathan P et al. (2015) Autonomic system and amyotrophic lateral sclerosis. Muscle Nerve 51:676-9
Limberg, Jacqueline K; Farni, Kathryn E; Taylor, Jennifer L et al. (2014) Autonomic control during acute hypoglycemia in type 1 diabetes mellitus. Clin Auton Res 24:275-83

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