Abstract

The Microscopy and Histopathology Laboratory provides a service to these members of the program project, whose work involves the evaluation of tissue or cell alterations that occur in response to HSV infection. Tissue will be embedded, sectioned, and stained. Microscopy services will be provided, including confocal microscopy. Dr Ehud Lavi, neuropathologist, will continue to provide anatomical advice on the sections.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS033768-15A2
Application #
6505131
Study Section
Project Start
1986-08-01
Project End
2006-08-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
15
Fiscal Year
2001
Total Cost
$200,768
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Sanders, Iryna; Boyer, Mark; Fraser, Nigel W (2015) Early nucleosome deposition on, and replication of, HSV DNA requires cell factor PCNA. J Neurovirol 21:358-69
Oh, Jaewook; Sanders, Iryna F; Chen, Eric Z et al. (2015) Genome wide nucleosome mapping for HSV-1 shows nucleosomes are deposited at preferred positions during lytic infection. PLoS One 10:e0117471
Brinkman, Kerry K; Mishra, Prakhar; Fraser, Nigel W (2013) The half-life of the HSV-1 1.5-kb LAT intron is similar to the half-life of the 2.0-kb LAT intron. J Neurovirol 19:102-8
Volcy, Ketna; Fraser, Nigel W (2013) DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line. J Neurovirol 19:57-64
Oh, Jaewook; Ruskoski, Nicholas; Fraser, Nigel W (2012) Chromatin assembly on herpes simplex virus 1 DNA early during a lytic infection is Asf1a dependent. J Virol 86:12313-21
Millhouse, Scott; Wang, Xiaohe; Fraser, Nigel W et al. (2012) Direct evidence that HSV DNA damaged by ultraviolet (UV) irradiation can be repaired in a cell type-dependent manner. J Neurovirol 18:231-43
Jiang, Xianzhi; Chentoufi, Aziz Alami; Hsiang, Chinhui et al. (2011) The herpes simplex virus type 1 latency-associated transcript can protect neuron-derived C1300 and Neuro2A cells from granzyme B-induced apoptosis and CD8 T-cell killing. J Virol 85:2325-32
Millhouse, Scott; Su, Ying-Hsiu; Zhang, Xianchao et al. (2010) Evidence that herpes simplex virus DNA derived from quiescently infected cells in vitro, and latently infected cells in vivo, is physically damaged. J Neurovirol 16:384-98
Smith, Sheryl T; Wickramasinghe, Priyankara; Olson, Andrew et al. (2009) Genome wide ChIP-chip analyses reveal important roles for CTCF in Drosophila genome organization. Dev Biol 328:518-28