The specimen core supports all activities of the UCSD SPOTRIAS site, and the SPOTRIAS national network,by arranging for the collection, storage, and shipment of specimens from patients with acute stroke, TIA, andmimic conditions.
Specific Aim 1 continues our routine procedures to obtain, process, and store bloodspecimens from acute patients at multiple time points. We have established blood-drawing protocols in theemergency departments, intensive care units, and general wards at our collaborating sites. A number ofprocedures ensure quality handling and labeling of all SPOTRIAS specimens.
Specific Aim 2 proposes toderive a panel of serum markers designed to help predict future ischemic events after transient ischemicattack (TIA). It is important to attempt to stratify TIA patients into high- and low-risk groups, and neither theABCD2 model nor serum biomarkers has been prospectivelv validated for this purpose. We will derive amulti-marker panel that shows good predictive value for estimating subsequent stroke risk, and thencompare the predictive value of the derived biomarker panel to the ABCD2 method. After consent, bloodsamples will be drawn as soon as practical after admission of TIA patients. Blood will be shipped to Biosite,Inc., for assay. The primary endpoint will be the 90-day incidence of new stroke after TIA. Secondaryendpoints will be the 90-day NIHSS and modified Rankin Scale. We will also compute an ABCD2 predictionfor each patient. We expect the clinical estimate, ABCD2, to predict subsequent stroke risk with reasonablepredictive value. We expect to be able to derive a multi-marker panel of biomarkers that also has areasonable AUC for the ROC curve. We will determine whether either method is superior to the other.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS044148-06
Application #
7505995
Study Section
Special Emphasis Panel (ZNS1-SRB-G (21))
Project Start
Project End
Budget Start
2008-07-01
Budget End
2009-04-30
Support Year
6
Fiscal Year
2008
Total Cost
$49,260
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
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Spokoyny, Ilana; Raman, Rema; Ernstrom, Karin et al. (2014) Imaging negative stroke: diagnoses and outcomes in intravenous tissue plasminogen activator-treated patients. J Stroke Cerebrovasc Dis 23:1046-50

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