The Xenograft Core for NF1 Experimental Therapeutics is designed to provide timely and cost-efficientaccess to animal models of neurofibromatosis-related cancers using human tumor derived cells. We havesuccessfully established human xenograft models of malignant peripheral nerve sheath tumors (MPNSTs) inathymic nude mice. While xenograft models in general are considered to be less authentic relative to humandisease then native, spontaneous tumor models, they have the advantage of being rapid, measurable andpredictable. Another important advantage for some types of biologic therapeutic applications is that xenografttumors are of human origin, and are therefore more appropriate for the study of agents directed attherapeutic targets that may differ in human and mouse cells (such as antibodies or gene-based therapiesusing human viruses). The Xenograft Core gives Cincinnati Center for Neurofibromatosis Researchmembers access to expertise and services they would otherwise need to individually acquire, providing aneconomy of effort. Services include maintenance and quality control of human cell lines, mouse injections fortumor formation, drug administration, animal monitoring and serial measurements of tumor growth, serialblood sampling for pharmacokinetic studies, necropsy and harvesting of tumor and organs for microscopicevaluation and pharmacodynamic (target validation) studies.
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