The 5-year renewal for Grant P51 RR00163-50 requests funding for programs at the ONPRC that support biomedical research. The application reflects a new strategic focus on interdisciplinary research to optimize the use and development of nonhuman primate (NHP) models.
The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which NHPs are used to accelerate progress in understanding human diseases;2) enhance the Center's resources (scientific expertise, laboratories, animal services, research support cores and equipment) so as to serve as a regional and national resource;3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-origin rhesus macaque breeding program;and 4) expand research programs utilizing NHPs in stem cell biology, aging, obesity, genetics, infectious diseases, vaccine development, neuroscience and women's health. To accomplish these aims, support is requested in three broad areas. First, Administration &Center Operations provide the administrative and service support required for all aspects of the ONPRC. Units include: 1) the Director's Office;2) Administrative Services (Business Services, Environmental Health &Radiation Safety, Facilities &Property, Information Technology &Engineering, and the Research Library);3) Animal Resources (Administration, Operations, Behavioral Services, Pathology Services, Surgery Services, and Clinical Medicine);and 4) Research Support Cores (Assisted Reproductive Technology, Endocrine Technology, Imaging &Morphology, Immunology, Magnetic Resonance Imaging, Molecular &Cellular Biology, and Virology &Serology). Secondy, Scientific Components include support for: 1) Scientific Divisions (Neuroscience, Pathobiology &Immunology, and Reproductive Sciences) and their interdisciplinary Working Groups (Biology of Aging, Metabolic Disease, and Stem Cell &Developmental Biology);2) the Collaborative Research Unit that facilitates externallyfunded research;3) the Pilot Project Program;and 4) Resource-Related Research. Finally, Improvement & Modernization includes funds for equipment and alterations and renovations.
The funds requested will provide support for the research infrastructure required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, including increased biodefense and HIV vaccine research, as well as translational research initiatives that are highly interdisciplinary in nature.
| O'Rand, Michael G; Hamil, Katherine G; Adevai, Tiffany et al. (2018) Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive. PLoS One 13:e0195953 |
| Gupta, Sandeep; Sivalingam, Daniel; Hain, Samantha et al. (2018) Deriving Dorsal Spinal Sensory Interneurons from Human Pluripotent Stem Cells. Stem Cell Reports 10:390-405 |
| Gall, Andrew J; Olds, June E; Wünschmann, Arno et al. (2018) LESIONS OF THE FEMALE REPRODUCTIVE TRACT IN JAPANESE MACAQUE ( MACACA FUSCATA) FROM TWO CAPTIVE COLONIES. J Zoo Wildl Med 49:79-85 |
| Balasubramanian, Preetha; Williams, Constance; Shapiro, Mariya B et al. (2018) Functional Antibody Response Against V1V2 and V3 of HIV gp120 in the VAX003 and VAX004 Vaccine Trials. Sci Rep 8:542 |
| Robinson, Lauren M; Coleman, Kristine; Capitanio, John P et al. (2018) Rhesus macaque personality, dominance, behavior, and health. Am J Primatol 80: |
| Allen, Daicia C; Gonzales, Steven W; Grant, Kathleen A (2018) Effect of repeated abstinence on chronic ethanol self-administration in the rhesus monkey. Psychopharmacology (Berl) 235:109-120 |
| McGill, Trevor J; Stoddard, Jonathan; Renner, Lauren M et al. (2018) Allogeneic iPSC-Derived RPE Cell Graft Failure Following Transplantation Into the Subretinal Space in Nonhuman Primates. Invest Ophthalmol Vis Sci 59:1374-1383 |
| Prola-Netto, Joao; Woods, Mark; Roberts, Victoria H J et al. (2018) Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure. Radiology 286:122-128 |
| Su, Weiping; Matsumoto, Steven; Sorg, Barbara et al. (2018) Distinct roles for hyaluronan in neural stem cell niches and perineuronal nets. Matrix Biol : |
| Haigwood, Nancy; Schultz, Alan (2018) Tribute to Bonnie Mathieson. J Med Primatol 47:286-287 |
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