Abstract

-OVERALL TheOregonNationalPrimateResearchCenter(ONPRC),locatedontheWestCampusofOregonHealth& ScienceUniversity(OHSU),requestsfundstorenewgrantP51-OD011092forthenextfive-yearperiod(May 1,2019-April30,2024).Currentlyinits59thyearofoperation,theONPRChasservedabroadrangeoflocal, regional,andnationalinvestigatorsperformingbiomedicalresearchinnonhumanprimate(NHP)modelswith thegoalofimprovinghumanhealth.ThegoalsforthenextfundingperiodarereflectedinthefollowingSpecific Aims:1)Conductstate-of-the-artresearchthatadvancesunderstandingofcausesandthedevelopmentof preventions,treatments,andcuresfordebilitatinghumandiseases;?2)ProvideexceptionalNHPexpertiseand servicestoresearchersatthelocal,regional,andnationallevelstoadvanceNIH-andotherfederally- supportedresearchprograms;?3)Pursuethehigheststandardsofhumaneandresponsibleanimalcare;?and4) MentorandtrainthenextgenerationoftranslationalNHPresearchersandeducatethepublicaboutthe importanceofbiomedicalresearch.Toaccomplishtheseaims,supportisrequestedinsevenbroadareas. Theseareasare:(1)Administration,whichprovidestheadministrativeandservicesupportrequiredforall aspectsoftheONPRC(Governance,Director?sOffice,BusinessServices,Facilities,Improvementsand Modernization,InformationSystems,ResearchLibrary,andResearchSafety);?(2)AnimalServices[Resources &Logistics,Operations,PathologyServices,SurgicalServices,BehavioralServices,EducationandTraining, ClinicalMedicine,andNHPResources(Obese,Aging,InfectiousDisease,andJapaneseMacaque)];?(3)Core ScienceServices[ResearchCores(AssistedReproductiveTechnologies,Bioinformatics&Biostatistics, EndocrineTechnologies,FlowCytometry,IntegratedPathology,MolecularTechnologies,MolecularVirology, MagneticResonanceImaging(MRI),andPrimateGenetics)];?(4)ScientificComponents,includingsupportfor ScientificDivisions(CardiometabolicHealth,Genetics,Neuroscience,Pathobiology&Immunology,and Reproductive&DevelopmentalSciences);?(5)PilotResearchProgram;?(6)OutreachandCommunity Engagement;?and(7)NPRCConsortium-BasedActivities. ONPRC?soverarchinggoalistodevelop,study,andshareNHPmodelsthatcaninformthecausesofhuman diseases,leadingtobetterpreventions,treatments,andcures.TheONPRCachievesthisgoalbysupporting translationalresearchandexpertiseinmodelsthatareprovidedlocally,regionally,andnationallyona collaborativebasis.Thehostinstitution,OHSU,recognizestheONPRCasoneoftheuniversity?s?topfive? strengthsandhaspledgedtocontinuesupportforprogrammaticintegrationandinfrastructuredevelopment.

Public Health Relevance

-OVERALL TheOregonNationalPrimateResearchCenter(ONPRC)isanestablishednationalresourcethathasasits primarymissiontheimprovementofhumanhealthandqualityoflifethroughsupportofexceptionalnonhuman primate(NHP)researchprogramsthatadvanceourknowledgeofthecauses,preventions,treatments,and curesofdebilitatingdiseases.TheONPRChostsrobustandwell-developedinternalresearchprograms,which arecomplementedbycollaborativeresearchprogramsthatservethegreaterbiomedicalresearchcommunity. TheONPRCmaintainsthefacilities,expertise,andinfrastructurerequiredtoconductthemostadvanced biomedicalresearchusingNHPsasmodelsofhumanhealthanddisease.Moreover,theONPRCcanmeet theneedsofnewemergingareasofbasicresearchinwhichtheNHPmodeliscritical,aswellastranslational researchinitiativesthatarehighlyinterdisciplinary.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011092-61S1
Application #
10178268
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Hild, Sheri Ann
Project Start
1997-05-01
Project End
2024-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
61
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
Primate Centers
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Edelman, Alison B; Jensen, Jeffrey T; McCrimmon, Sara et al. (2018) Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception 98:463-466
Jimenez, Vanessa A; Wang, Xiaojie; Newman, Natali et al. (2018) Detecting neurodevelopomental effects of early-gestation ethanol exposure: a non-human primate model of ethanol drinking during pregnancy. Alcohol Clin Exp Res :
Haigwood, Nancy L (2018) Antibodies pose a double threat to HIV. Nature 561:468-470
Ma, Hong; Lee, Yeonmi; Hayama, Tomonari et al. (2018) Germline and somatic mtDNA mutations in mouse aging. PLoS One 13:e0201304
Bishop, Cecily V; Mishler, Emily C; Takahashi, Diana L et al. (2018) Chronic hyperandrogenemia in the presence and absence of a western-style diet impairs ovarian and uterine structure/function in young adult rhesus monkeys. Hum Reprod 33:128-139
Jeon, Sookyoung; Ranard, Katherine M; Neuringer, Martha et al. (2018) Lutein Is Differentially Deposited across Brain Regions following Formula or Breast Feeding of Infant Rhesus Macaques. J Nutr 148:31-39
Horikoshi, Momoko; Day, Felix R; Akiyama, Masato et al. (2018) Elucidating the genetic architecture of reproductive ageing in the Japanese population. Nat Commun 9:1977
Ozawa, Koya; Packwood, William; Varlamov, Oleg et al. (2018) Molecular Imaging of VWF (von Willebrand Factor) and Platelet Adhesion in Postischemic Impaired Microvascular Reflow. Circ Cardiovasc Imaging 11:e007913
Xu, Jing; Lawson, Maralee S; Mitalipov, Shoukhrat M et al. (2018) Stage-specific modulation of antimüllerian hormone promotes primate follicular development and oocyte maturation in the matrix-free three-dimensional culture. Fertil Steril 110:1162-1172
Hessell, Ann J; Shapiro, Mariya B; Powell, Rebecca et al. (2018) Reduced cell-associated DNA and improved viral control in macaques following passive transfer of a single anti-V2 monoclonal antibody and repeated SHIV challenges. J Virol :

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