Abstract

? Vector-Borne Diseases Core The Vector-Borne Diseases Core produces tick vectors for research on Lyme disease and other tick-borne diseases. All of the developmental stages of the hard tick Ixodes scapularis are available for research purposes. The Core is run by Mary Jacobs, MS, under the direction of Monica Morici-Embers, PhD. During the last funding period, the Core made useful improvements to the techniques of tick feeding on animals. These changes facilitated the use of xenodiagnosis, a procedure that is very sensitive for detection of living spirochetes in animals with low-level infections. The types of services provided include the provision of ticks for: 1) Tick- mediated infection, 2) Capillary feeding of ticks, 3) Xenodiagnosis, and 4) Collection of tick saliva. All of the service capabilities of the Core were utilized this funding period, and a large number of ticks (6720) were generated. The Core has been very productive and has fostered a large number of collaborations.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
2P51OD011104-57
Application #
9568198
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2018-05-01
Budget End
2019-04-30
Support Year
57
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Tulane University
Department
Type
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118

  Publications

Xu, Huanbin; Ziani, Widade; Shao, Jiasheng et al. (2018) Impaired Development and Expansion of Germinal Center Follicular Th Cells in Simian Immunodeficiency Virus-Infected Neonatal Macaques. J Immunol 201:1994-2003
Scarritt, Michelle E; Pashos, Nicholas C; Motherwell, Jessica M et al. (2018) Re-endothelialization of rat lung scaffolds through passive, gravity-driven seeding of segment-specific pulmonary endothelial cells. J Tissue Eng Regen Med 12:e786-e806
Wang, Xiaolei; Xu, Huanbin (2018) Potential Epigenetic Regulation in the Germinal Center Reaction of Lymphoid Tissues in HIV/SIV Infection. Front Immunol 9:159
Delery, Elizabeth C; MacLean, Andrew G (2018) Chronic Viral Neuroinflammation: Speculation on Underlying Mechanisms. Viral Immunol :
Sokolova, Yuliya Y; Bowers, Lisa C; Alvarez, Xavier et al. (2018) Encephalitozoon cuniculi and Vittaforma corneae (Phylum Microsporidia) inhibit staurosporine-induced apoptosis in human THP-1 macrophages in vitro. Parasitology :1-11
Mahalingam, Ravi; Kaufer, Benedikt B; Ouwendijk, Werner J D et al. (2018) Attenuation of Simian Varicella Virus Infection by Enhanced Green Fluorescent Protein in Rhesus Macaques. J Virol 92:
Sherrill-Mix, Scott; McCormick, Kevin; Lauder, Abigail et al. (2018) Allometry and Ecology of the Bilaterian Gut Microbiome. MBio 9:
Langsjoen, Rose M; Haller, Sherry L; Roy, Chad J et al. (2018) Chikungunya Virus Strains Show Lineage-Specific Variations in Virulence and Cross-Protective Ability in Murine and Nonhuman Primate Models. MBio 9:
Kumar, Vinay; Mansfield, Joshua; Fan, Rong et al. (2018) miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPAR? and Occludin Expression in Chronic Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Immunol 200:2677-2689
Sestak, Karol; Dufour, Jason P; Liu, David X et al. (2018) Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease. Front Immunol 9:1603

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