? Pilot Research Program In accordance with the NPRC guidelines and the FOA, the Tulane National Primate Research Center (TNPRC) Pilot Research Program provides funding to investigators who show promise of developing a career in nonhuman primate biomedical research or to those who wish to add a nonhuman primate component to an existing research program. The Pilot Research Program is also open to investigators with established nonhuman primate research programs who wish to develop substantially new research directions. Research may involve initial model identification, characterization, and development that may follow a case workup of a spontaneously occurring disease, evaluation of improved husbandry or animal management procedures, or more detailed examination of serendipitous laboratory findings. Pilot Research Program support is typically for proposals that do not have sufficient preliminary data or results that are needed to obtain support from normal sources of funding. The overall purpose of the project must complement the objectives of the Center?s research programs, and the projects themselves must have the potential of leading to an extramurally funded grant application. The proposal must be substantially different from the applicant?s funded projects. Investigators must be beyond the postdoctoral rank and based at any non-profit academic or research institution. If the applicant is not a TNPRC Core Staff Scientist, they must secure sponsorship from such a Core Scientist. The latter will assume responsibility for overall management, coordination and reports concerning the project. In general, all major activities related to the approved project must be conducted and carried out on site at the Center. The number of extramural grants that were awarded this funding period, made possible by Pilot Grants was 12. There were 3 RO1 grants, 3 R21 grants, and one grant of each of the following types: R33, COBRE, R56, P20, Foundation, and DoD. The number of papers published during this funding period based on experiments funded with pilot grants was 27.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
5P51OD011104-58
Application #
9741862
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
58
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Kumar, Vinay; Mansfield, Joshua; Fan, Rong et al. (2018) miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPAR? and Occludin Expression in Chronic Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Immunol 200:2677-2689
Sestak, Karol; Dufour, Jason P; Liu, David X et al. (2018) Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease. Front Immunol 9:1603
Ramsey, J; Martin, E C; Purcell, O M et al. (2018) Self-injurious behaviours in rhesus macaques: Potential glial mechanisms. J Intellect Disabil Res 62:1008-1017
Magnani, Diogo M; Rogers, Thomas F; Maness, Nicholas J et al. (2018) Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques. Nat Commun 9:1624
Dufour, Jason P; Russell-Lodrigue, Kasi E; Blair, Robert V (2018) Pseudoaneurysm and Arteriovenous Fistula in a Rhesus Macaque (Macaca mulatta). Comp Med 68:74-79
Parthasarathy, Geetha; Philipp, Mario T (2018) Intracellular TLR7 is activated in human oligodendrocytes in response to Borrelia burgdorferi exposure. Neurosci Lett 671:38-42
He, Ziyuan; Allers, Carolina; Sugimoto, Chie et al. (2018) Rapid Turnover and High Production Rate of Myeloid Cells in Adult Rhesus Macaques with Compensations during Aging. J Immunol 200:4059-4067
Pan, Diganta; Das, Arpita; Srivastav, Sudesh K et al. (2018) Lack of T-cell-mediated IL-2 and TNF? production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection. J Gen Virol :
Kuroda, Marcelo J; Sugimoto, Chie; Cai, Yanhui et al. (2018) High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Infect Dis 217:1865-1874
Laddy, Dominick J; Bonavia, Aurelio; Hanekom, Willem A et al. (2018) Toward Tuberculosis Vaccine Development: Recommendations for Nonhuman Primate Study Design. Infect Immun 86:

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