We are evaluating cognitive function in the oldest members of the ORPRC's Primate Aging Colony, six males and one female ranging from 28 to 32 years of age, in comparison with younger adults which are 8 to13 years old. In collaboration with Drs. Mark Moss and Douglas Rosene of the Boston University's Laboratory of the Neurobiology of Aging, a cognitive assessment battery has been designed and testing methods have been standardized across the two sites. The battery includes the delayed non-matching to sample task, a classic test of visual recognition memory, and the delayed recognition span task, which measures memory capacity. We also plan to construct an automated system to administer an attentional set-shifting task which is dependent on frontal lobe function and is selectively impaired in human aging and dementia. In addition we are evaluating other aspects of behavior, including behavioral reactivity as assessed with a test designed for evaluating effects of limbic s ystem damage, and motor deficits using a primate adaptation of a clinical Parkinson's symptoms rating scale. In preliminary results for the delayed non-matching to sample task, the older animals all have required several hundred more trials to achieve criterion performance (90% correct over 100 trials) than any of the younger group. In the behavioral reactivity task, no differences were found in the two age groups' responses to a variety of objects and social stimuli. Thus, impaired performance in the delayed non-matching to sample task is not related to negative responses to the variety of objects used as stimuli in the task. These ongoing studies will allow us to (1) assess cognitive and behavioral changes in a valuable group of primates of advanced age, and (2) relate these behavioral changes to quantitative measures of brain atrophy obtained by magnetic resonance imaging, measures of endocrine status, and neuropathological and molecular biological changes which will be evaluated at the end of their lifespan. FUNDING Nonfederal institutional funds PUBLICATIONS None

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
7P51RR000163-41
Application #
6312838
Study Section
Project Start
1978-05-01
Project End
2004-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
41
Fiscal Year
2000
Total Cost
$116,898
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239
Okoye, Afam A; Hansen, Scott G; Vaidya, Mukta et al. (2018) Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound. Nat Med 24:1430-1440
Jensen, Jeffrey T; Hanna, Carol; Mishler, Emily et al. (2018) Effect of menstrual cycle phase and hormonal treatments on evaluation of tubal patency in baboons. J Med Primatol 47:40-45
Toro, C A; Aylwin, C F; Lomniczi, A (2018) Hypothalamic epigenetics driving female puberty. J Neuroendocrinol 30:e12589
Bulgarelli, Daiane L; Ting, Alison Y; Gordon, Brenda J et al. (2018) Development of macaque secondary follicles exposed to neutral red prior to 3-dimensional culture. J Assist Reprod Genet 35:71-79
Prola-Netto, Joao; Woods, Mark; Roberts, Victoria H J et al. (2018) Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure. Radiology 286:122-128
Moccetti, Federico; Brown, Eran; Xie, Aris et al. (2018) Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries. J Am Coll Cardiol 72:1015-1026
Blue, Steven W; Winchell, Andrea J; Kaucher, Amy V et al. (2018) Simultaneous quantitation of multiple contraceptive hormones in human serum by LC-MS/MS. Contraception 97:363-369
Jeon, Sookyoung; Li, Qiyao; Rubakhin, Stanislav S et al. (2018) 13C-lutein is differentially distributed in tissues of an adult female rhesus macaque following a single oral administration: a pilot study. Nutr Res :
Slayden, Ov Daniel; Friason, Francis Kathryn E; Bond, Kise Rosen et al. (2018) Hormonal regulation of oviductal glycoprotein 1 (OVGP1; MUC9) in the rhesus macaque cervix. J Med Primatol 47:362-370
Dissen, G A; Adachi, K; Lomniczi, A et al. (2017) Engineering a gene silencing viral construct that targets the cat hypothalamus to induce permanent sterility: An update. Reprod Domest Anim 52 Suppl 2:354-358

Showing the most recent 10 out of 492 publications