This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levonorgestrel (LNG) releasing implants (e.g., Norplant), and LNG -releasing intrauterine devices (LNG-IUS; e.g., Mirena IUS) are very effective methods of contraception for women. However, women using these methods frequently experience breakthrough uterine bleeding that often leads them to discontinue this form of contraception. Rhesus macaques also display breakthrough bleeding when treated with LNG-IUS, and can provide a useful animal model for assessing novel therapies to control the bleeding. Our goal in research is to utilize rhesus macaques to further characterize the effect of LNG-IUS on the endometrium, and to test intermittent progesterone antagonist therapy as a treatment for uterine bleeding triggered by LNG-IUS use.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000163-47
Application #
7348903
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
47
Fiscal Year
2006
Total Cost
$76,828
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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