This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Levonorgestrel (LNG) releasing implants (e.g., Norplant), and LNG -releasing intrauterine devices (LNG-IUS; e.g., Mirena IUS) are very effective methods of contraception for women. However, women using these methods frequently experience breakthrough uterine bleeding that often leads them to discontinue this form of contraception. Rhesus macaques also display breakthrough bleeding when treated with LNG-IUS, and can provide a useful animal model for assessing novel therapies to control the bleeding. Our goal in research is to utilize rhesus macaques to further characterize the effect of LNG-IUS on the endometrium, and to test intermittent progesterone antagonist therapy as a treatment for uterine bleeding triggered by LNG-IUS use.
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