This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project examines the effect of estrogen (E) and progesterone (P) on serotonin neural function in macaques. Serotonin governs many autonomic and higher order neural functions. The ability of E and P to alter serotonin function thus impacts all of the systems that are regulated by serotonin. We have found that E and P alter gene and protein expression in serotonin neurons in a fashion that would increase serotonin neurotransmission. An elevation in serotonin neurotransmission is expected to benefit arousal, elevate mood and improve cognitive function. We are now pursuing the hypothesis that ovarian hormones also improve serotonin neuron survival.
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