This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The primate oviduct undergoes dramatic, hormonally-regulated changes in morphological structure. For instance, estrogen secreted from the ovary during the follicular phase of the menstrual cycle stimulates the oviductal epithelium to differentiate into two distinct cell types, ciliated cells and secretory cells. Paradoxically, estrogen receptors are absent from the ciliated cells, and the mechanism through which estrogen stimulates and maintains the ciliated phenotype is not known. The goal of this study is to use a new, focused gene array approach to search for potential factors that mediate the action of estrogen on the oviductal epithelium.
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