The 5-year renewal for Grant P51 RR00163-45 requests funding for programs that support biomedical research at the ONPRC. The application reflects a significant expansion in animal resources and research service cores that is required to support the growth in research programs (external grant funding has doubled during the past 5 years) and to greatly expand the Specific Pathogen Free (SPF) Indian-derived Rhesus Breeding Colony.
The aims of this application are to: 1) provide the infrastructure support necessary to conduct advanced biomedical research for which nonhuman primates (NHPs) are used to accelerate progress in understanding human diseases, leading to better health;2) enhance the Center's resources (scientific expertise, laboratories, animal services, research service cores and equipment) so as to serve as a regional, national and international resource;3) increase the availability of defined NHPs for biomedical research through support of our programs to expand the SPF Indian-derived Rhesus macaque breeding program that produces animals free of viruses such as herpes B and with defined parentage and genotype;and 4) expand research programs utilizing NHPs in genetics, infectious diseases and vaccine development, aging, neuroscience and women's health. To accomplish these aims, support is requested in four broad areas. Administration and Center Operations provide the administrative and service support that is required for all aspects of the ONPRC. Units include the Director's Office, Business Services, Facilities and Property, and Information Technology and Engineering. Research Infrastructure encompasses the service units that provide the most technologically advanced research support, such as Animal Resources (Business and Research Coordination, Clinical Medicine, NHP Resources, Operations, Pathology Services, Psychological Well Being and Surgery Services), Research Service Cores (Assisted Reproductive Technology, Electrophysiology, Endocrine Services, Flow Cytometry, Imaging and Morphology, Molecular and Cellular Biology, Monoclonal Antibody, Research Library, and Virology) and Special Resources Programs (Alternative NHP Species, Genetics Resource and Informatics, Aging NHPs and Rhesus Breeding). Scientific Resources includes support for the three research divisions that house ONRPC scientists: the Divisions of Pathobioloqy and Immunolo,qy, Neuroscience, and Reproductive Sciences. Funding is also requested for 4 resource-related research projects and the pilot project program. Improvement and Modernization includes funds for equipment and alterations and renovations.

Public Health Relevance

The funds requested will provide support for the research infrastructure that is required to conduct the most advanced biomedical research using NHPs as models of human health and disease, and to meet the needs of new emerging areas of research in which the NHP model is critical, such as functional genomics and biodefense initiatives.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
3P51RR000163-50S1
Application #
7880394
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Program Officer
Harding, John D
Project Start
2009-09-07
Project End
2012-09-06
Budget Start
2009-09-07
Budget End
2012-09-06
Support Year
50
Fiscal Year
2009
Total Cost
$280,416
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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