We provide, as a service, a method for cycle synchronization and prolonged luteal phase as required by other investigators. These investigators require that a group of female rhesus monkeys be in the mid-luteal phase of a normal menstrual cycle, all on the same day, so that the same virus inoculums could be used for vaginal inoculation. This synchronization is provided as follows The monkeys are observed daily for indications of menses. When it occurs, each monkey is then injected with progesterone starting on day 16 of that cycle. When all study monkeys have received at least 8 days of progesterone the injections are stopped. Menses occurs 2-3 days of the last progesterone injection. On day 16 of that cycle the monkeys began a second series of progesterone injections. The inoculations are done on a single day during this last series of progesterone. This procedure has provided study groups of 10 or more monkeys, all synchronized + 1 day in their cycle stage and maintained in a luteal stage for up to 21

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000164-37
Application #
6277444
Study Section
Project Start
1998-09-30
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Tulane University
Department
Type
DUNS #
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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Yi, Fei; Guo, Jia; Dabbagh, Deemah et al. (2017) Discovery of Novel Small-Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1. J Virol 91:
Jorgensen, Matthew J; Lambert, Kelsey R; Breaux, Sarah D et al. (2017) Pair housing of Vervets/African Green Monkeys for biomedical research. Am J Primatol 79:1-10
Ramesh, Geeta; Martinez, Alejandra N; Martin, Dale S et al. (2017) Effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in glial and neuronal cells of the central nervous system. J Neuroinflammation 14:28
Parthasarathy, Geetha; Philipp, Mario T (2017) Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi. J Neuroinflammation 14:110

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