This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.In this study we further investigated the use of the Energex Systems Hemo-Modulator (H-M) to control Simian Immunodeficiency Virus (SIV) in infected macaques. This medical device treats whole blood with high energy irradiation with the purpose of immune enhancement. Two animals were previously vaccinated with VSV containing HIV gag genes. One animal was boosted with VSV containing avian flu genes, the other received no vaccine boost. On Day 0, both animals were treated with the H-M. Blood samples were taken on Day-3 (prior to vaccination), Day 0 (prior to H-M treatment), 16 hours, 24 hours, 5 days and 7 days post H-M treatment.A second group consisting of 2 SIV-infected rhesus macaques were treated and samples collected as described above. RNA extracted from blood cell was subjected to Microarray analysis in the Tulane National Primate Research Center Microarray core. The analysis of extensive quantities of data collected is ongoing.
Showing the most recent 10 out of 352 publications