This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We investigated pathogenesis and transmissibility of SHIVSF162P3N (P3N) and the clone, whether the clone could fully recapitulate the in vivo replicative characteristics of the parental isolate. Both SHIVSF162P3N, (P3N) and the clone were mucosally transmissible, preferentially depleted memory CD4 T cells. Fifteen (15) animals were rectally challenged, 3 animals with P3N plus clone and 12 animals with the clone alone. Both virus infected rectally, 6/12 animals controlled the virus in the clone group, whereas one animals challenged with the mixture virus ( P3N and clone) was able to control the virus. Preliminary results indicate that both virus were transmitted mucosally with no significant difference in viral set points and progression to disease.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000164-49
Application #
8172945
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2010-05-01
Project End
2011-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
49
Fiscal Year
2010
Total Cost
$61,801
Indirect Cost
Name
Tulane University
Department
Type
Other Domestic Higher Education
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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