SPID#: 25 The objective of this research is to evaluate the toxicity and/or immunosuppressive effects of novel drug combinations with assessment of transport and metabolic disposition. In particular, effects of selected modulating agents on anti-HIV drugs will be studied in an attempt to prevent or alleviate bone marrow toxicity associated with chronic treatment with certain anti-HIV nucleoside analogs. Pharmacokinetics of anti-HIV drugs and modulation will be studied. Efficacy of selected drug combinations (anti-HIV and modulating agent) will eventually be assessed in SIV-infected rhesus monkeys.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000165-36
Application #
5219880
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
36
Fiscal Year
1996
Total Cost
Indirect Cost
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