Abstract

Because aged nonhuman primates show ?-amyloid (A?) deposition in senile plaques and blood vessels similar to that seen in human aging and AD, C-terminal-specific antibodies to A?40 and A?42 were used to investigate A? peptide length in the brains of 11 aged rhesus monkeys and a 59-year-old chimpanzee. In contrast to AD, where the earliest and most prominent form of A? in senile plaques is A?42 in the monkey, A?40-positive plaques predominated. The ratio of A?40:A?42-positive plaques averaged 2.08 in the monkey, as compared to a mean ratio of 0.37 in 68 human AD subjects (p < 0.001). A?40 was also more prominent in the chimpanzee than in humans. Possible explanations for these findings include species differences in the cleavage of A? from the amyloid precursor protein or in the activity of a putative carboxy peptidase forming A?40 from A?42 in situ.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
3P51RR000165-37S1
Application #
2711873
Study Section
Project Start
Project End
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Beck, Goichi; Maehara, Shunsuke; Chang, Phat Ly et al. (2018) A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. Mov Disord 33:805-814
Georgieva, Maria; Sia, Jonathan Kevin; Bizzell, Erica et al. (2018) Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun 86:
Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97
Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:
Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319
Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105
Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198
Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952
Maddox, S A; Kilaru, V; Shin, J et al. (2018) Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry 23:658-665
Li, Chun-Xia; Kempf, Doty J; Tong, Frank C et al. (2018) Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures. Comp Med :

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