Immunopathology of Acute SIV Infection

Novembre, Francis J.

Abstract

In collaboration with Dr. Stephen Dewhurst at the University of Rochester, we have been examining the immunopathology of acute SIVsmmPBj infection in macaques. Our research has focused on the mechanism of acute disease development. Previous studies of ours have shown that animals developing acute disease following SIVsmmPBj infection show increased levels of apoptosis and upregulation of an intestinal-specific integrin. New results have shown that this virus induces an increased level of Fas ligand expression and requires co-stimulatory molecules for inducing PBMC activation. Taken together these data strongly suggest that immune activation is an important element in PBj pathogenesis. FUNDING NIH / AI 39397 $83,143 4/01/96 - 3/31/99 PUBLICATIONS Hodge, S.M., Novembre, F.J. and Dewhurst, S. Endogenous tumor necrosis factor-( contributes to lymphoproliferation induced by simian immunodeficiency virus variant, SIVsmmPBj14. Immunol Lett 63:49-51, 1998. Hodge, S., Novembre, F.J., Whetter, L., Gelbard, H.A. and Dewhurst, S. Induction of fas ligand expression by an acutely lethal simian immunodeficiency virus, SIVsmmPBj14. Virol 252(2):354-363, 1998. Whetter, L., Novembre, F.J., Saucier, M.M., Gummuluru, S. and Dewhurst, S. Costimulatory pathways in lymphocyte proliferation induced by simian immunodeficiency virus, SIVsmmPBj14. J Virol 72:6155-6158, 1998. P51RR00165-38 1/1/1998 - 12/31/1998 Yerkes Regional Primate Research Center

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Primate Research Center Grants (P51)
• Project #: 5P51RR000165-39
• Application #: 6116241
• Project Start: 1999-05-01
• Project End: 2000-04-30
• Budget Start: 1998-10-01
• Budget End: 1999-09-30
• Support Year: 39
• Fiscal Year: 1999

Institution

• Name: Emory University
• DUNS #: 042250712
• City: Atlanta
• State: GA
• Country: United States
• Zip Code: 30322

Publications

Claw, Katrina G; George, Renee D; MacCoss, Michael J et al. (2018) Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems. BMC Genomics 19:488

Adekambi, Toidi; Ibegbu, Chris C; Cagle, Stephanie et al. (2018) High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis. Front Immunol 9:1481

Beck, Goichi; Maehara, Shunsuke; Chang, Phat Ly et al. (2018) A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. Mov Disord 33:805-814

Georgieva, Maria; Sia, Jonathan Kevin; Bizzell, Erica et al. (2018) Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun 86:

Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97

Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:

Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319

Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105

Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198

Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952