Structural Evolution of Primate Brain

Insel, Thomas R.

Abstract

This project has established a database for comparative neuroanatomy of primates using high resolution magnetic resonance imaging (MRI). A total of 44 animals were scanned, including representatives of every species listed above and all of these scans have been reconstructed to provide surface rendering and volumetric measures. Digitized versions of these scans have been stored on compact disc for distribution to investigators interested in primate brain evolution. Our own analysis has demonstrated 1) a decrease in relative cerebellar volume in humans compared to apes; 2) a decrease in relative corpus callosum size in the human brain; and 3) a relative increase in intra-hemispheric projections in the human brain. These studies provide the first MRI database for studies of comparative primate brain evolution and should yield novel insights into differences between human and non-human primate neuroanatomy. FUNDING MacArthur Foundation $40,000 9/01/96 - 2/28/98 Leakey Foundation $ 7,500 1/01/97 - 12/31/99 PUBLICATIONS Rilling, J.K. and Insel, T.R. Differential expansion of neural projection systems in primate brain evolution. NeuroReport (In press). Rilling, J.K. and Insel, T.R. Evolution of the cerebellum in primates Differences in relative volume among monkeys, apes, and humans. Brain, Behavior and Evolution 52:308-314, 1998. Rilling, J.K. and Insel, T.R. The primate neocortex in comparative perspective using magnetic resonance imaging. Human Evolution (In press). P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Primate Research Center Grants (P51)
• Project #: 5P51RR000165-39
• Application #: 6116274
• Project Start: 1999-05-01
• Project End: 2000-04-30
• Budget Start: 1998-10-01
• Budget End: 1999-09-30
• Support Year: 39
• Fiscal Year: 1999

Institution

• Name: Emory University
• DUNS #: 042250712
• City: Atlanta
• State: GA
• Country: United States
• Zip Code: 30322

Publications

Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97

Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:

Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319

Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105

Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198

Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952

Maddox, S A; Kilaru, V; Shin, J et al. (2018) Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD. Mol Psychiatry 23:658-665

Li, Chun-Xia; Kempf, Doty J; Tong, Frank C et al. (2018) Longitudinal MRI Evaluation of Ischemic Stroke in the Basal Ganglia of a Rhesus Macaque (Macaca mulatta) with Seizures. Comp Med :

Lacreuse, Agnès; Parr, Lisa; Chennareddi, Lakshmi et al. (2018) Age-related decline in cognitive flexibility in female chimpanzees. Neurobiol Aging 72:83-88

Meng, Yuguang; Hu, Xiaoping; Zhang, Xiaodong et al. (2018) Diffusion tensor imaging reveals microstructural alterations in corpus callosum and associated transcallosal fiber tracts in adult macaques with neonatal hippocampal lesions. Hippocampus 28:838-845