Abstract

The dopamine transporter is a key target or """"""""receptor"""""""" for cocaine that mediates its addicting properties. Therefore, understanding the factors which control the levels of dopamine transporter in brain is essential for understanding mechanisms of drug addiction. This project plans to develop a method to measure the synthesis rate and degradation rate of the dopamine transporter, and the serotonin transporter as well. The serotonin transporter is important because it is a target or receptor for antidepressant drugs. Substantial progress has been made in that the serotonin transporter turnover has been measured and its half-life is 3.4 days. We are in the process of determining the same factors for the dopamine transporter. FUNDING NIH / DA11178 $141,199 08/01/97 - 06/30/00 PUBLICATIONS Boja, J.W., Carroll, F.I., Vaughan, R.A., Kopajtic, T. and Kuhar, M.J. Multiple binding sites for [125I]RTI-121 and other cocaine analogs in rat frontal cerebral cortex. Synapse 30:9-17, 1998. Ding, Y.-S., Molina, P.E., Fowler, J.S., Logan, J., Volkow, N.D., Kuhar, M.J. and Carroll, F.I. Comparative studies of epibatidine derivatives [18F]NFEP and [18F]N-methyl-NFEP Kinetics, nicotine, effect, and toxicity. Nucl. Med. Biol. 25:139-148, 1999. Kuhar, M. Neurotransmitter transporters are NOT in the Synapse? Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, December 7-16th. Invited Symposium. Kuhar, M.J., Vaughan, R., Uhl, G., Cerruti, C., Revay, R., Freed, C., Nirenburg, M. and Pickel, V. Localization of dopamine transporter protein by microscopic histochemistry. Adv. Pharmacol. 42:168-170, 1998. Vaughan, R.A., Huff, R.A., Uhl, G.R. and Kuhar, M.J. Phosphorylation of dopamine transporters and rapid adaptation to cocaine, in Goldstein, D.S., Eisenhofer, G., and McCarty, R. (Eds.) Catecholamines Bridging Basic Science with Clinical Medicine, Academic Press, San Diego, pp. 1042-, 1998. P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000165-40
Application #
6311823
Study Section
Project Start
1976-06-01
Project End
2001-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
40
Fiscal Year
2000
Total Cost
$38,495
Indirect Cost

  Institution

Name
Emory University
Department
Type
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322

  Publications

Claw, Katrina G; George, Renee D; MacCoss, Michael J et al. (2018) Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems. BMC Genomics 19:488
Adekambi, Toidi; Ibegbu, Chris C; Cagle, Stephanie et al. (2018) High Frequencies of Caspase-3 Expressing Mycobacterium tuberculosis-Specific CD4+ T Cells Are Associated With Active Tuberculosis. Front Immunol 9:1481
Beck, Goichi; Maehara, Shunsuke; Chang, Phat Ly et al. (2018) A Selective Phosphodiesterase 10A Inhibitor Reduces L-Dopa-Induced Dyskinesias in Parkinsonian Monkeys. Mov Disord 33:805-814
Georgieva, Maria; Sia, Jonathan Kevin; Bizzell, Erica et al. (2018) Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun 86:
Tedesco, Dana; Grakoui, Arash (2018) Environmental peer pressure: CD4+ T cell help in tolerance and transplantation. Liver Transpl 24:89-97
Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:
Walker, Lary C (2018) Prion-like mechanisms in Alzheimer disease. Handb Clin Neurol 153:303-319
Kamberov, Yana G; Guhan, Samantha M; DeMarchis, Alessandra et al. (2018) Comparative evidence for the independent evolution of hair and sweat gland traits in primates. J Hum Evol 125:99-105
Wakeford, Alison G P; Morin, Elyse L; Bramlett, Sara N et al. (2018) A review of nonhuman primate models of early life stress and adolescent drug abuse. Neurobiol Stress 9:188-198
Singh, Arun; Jenkins, Meagan A; Burke Jr, Kenneth J et al. (2018) Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates. Cell Rep 22:941-952

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