This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of this project is to examine phenyltropane analogs of cocaine as potential medications for cocaine addicts. The synthesis and properties of various methyl ester isomers, paraoxetine analogs and norepinephrine-specifc compounds were examined in the past year. In addition to characterizing these novel compounds, we have shown that many of these compounds have psychostimulant-like properties, which is important given our goal. Results from these studies also clarified how various compounds interact with the dopamine, serotonin and norepinephrine transporter. The data indicate that these compounds may have properties desirable in potential medications.
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