This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The objective of this project is to identify the neuronal mechanisms that support memory performance on the VPLT in awake, behaving monkeys. In the past year, we accumulated new data which demonstrated that increased gamma-frequency (40-100 Hz) synchronization among hippocampal neurons is associated with enhanced recognition memory. Increased synchrony during encoding predicts successful subsequent recognition memory performance. Increased neuronal synchronization within the hippocampus serves to enhance the selected stimulus representation in the hippocampal circuitry. Correspondingly, this synchronization could also serve to modify neocortical neurons, perhaps for memory consolidation.
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