This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This project is designed to develop a radioligand that can be used in PET neuroimaging to quantity estrogen receptor (ER) binding density in brain of monkeys. In conjunction the radiochemistry in Radiology, the initial phase of the project is to synthesize a ligand that has been used successfully to image ER is breast tissue. This has been accomplished and the project is now focused on performing autoradiography with this ligand on hypothalamic tissue from a rhesus monkey female. Once this is accomplished, plans are to use this ligand to image ER in the brain in vivo using PET.
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