This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.We continue to examine NMDA function in mice through the use of a 'floxed' inducible deletion NMDA receptor subunit 1 mouse line. We focused on NMDA subtypes and the localization of gene expression of NMDA2b, 2c, and type 1 receptors. Finally, our work continues on the plasticity factor, BDNF, and its role along with NMDA in mediating plasticity of fear and extinction of fear. Additionally, we submitted the IRB for the human D-cycloserine study. Our collaboration continues with a treatment study for D-cycloserine augmentation of treatment for PTSD at Emory and the Atlanta VA Medical Center. Pilot trials for gene therapy approaches using lentiviral vectors in the Macaque amygdala to examine effects on emotional responsiveness are scheduled to begin in the near future.
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