This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.This management study treats Yerkes' colonies of SIV-infected and uninfected sooty mangabeys (SMs) as cohorts for which a periodic immuno-virological evaluation is conducted and a repository of frozen samples of plasma and PBMCs are stored and made available for selected research projects to both Yerkes and non-Yerkes investigators. An extensive survey of the Yerkes SMs was first completed in 2004 and then repeated during 2006/07, during which time approximately 170 samples were collected and analyzed The samples utilized from this project have been instrumental to several important publications in the field. This general approach should also enable us to generate a set of immunological and virological data to conduct a systematic longitudinal assessment of the animals' health status, with specific focus on the course of SIV infection. This set of data will also allow the rapid and effective identification of SMs with specific immunological and/or virological features, and to match against the SM colony pedigree which is just being completed.
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