This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Socio-environmental factors significantly affect the risk for developing a number of behavioral and psychiatric disorders in people, including anxiety, depression, eating disorders, and addiction. It is becoming increasingly clear that some individuals are more susceptible to developing these pathologies and that this increased risk may be attributed to genetic factors. The goal of this project is to conduct an analysis of the genetic heritabilities of a number of biobehavioral and physiological traits that have been demonstrated to be of relevance for psychiatric disorders, followed by linkage and association analysis of candidate genes and gene polymorphisms that account for individual differences in these characteristics using the pedigreed rhesus monkey population at the Field Station. This project was initiated in the current year. Physiological data, including anthropometric measures, serum for metabolic and stress hormone analyses, and CSF for neurotransmitter analysis were collected on the first cohort of animals. In addition, behavioral data were obtained to characterize social status position and rates of affiliative, agonistic, and anxiety-like behavior. This proposal will generate a database of information that be used by investigators to pursue funding opportunities that investigate gene environment interactions that contribute to the behavioral health of people.
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