The goal of this research is to uncover the neuronal mechanisms that limit the development of visual performance in primates. Recent advances in visual psychophysics and theory have made it possible to formulate questions about visual development in the same terms used to analyze adult vision, and we are conducting experiments to explore the neurobiology of development in these functional terms. The experiments in this project hinge on the measurement of visual efficiency, the fidelity with which contrast is encoded in the visual system. Contrast thresholds measured behaviorally in the presence or absence of masking noise are assessed in infant macaques as a function of age. We confirmed that, as the animals mature, visual efficiency improves with contrast sensitivity. To try to establish the underlying mechanisms we recorded from neurons in lateral geniculate nucleus (LGN) and primary visual cortex (V1) in newborns. We found that the degree of improvement in sensitivity and resolution of neurons in LGN was not substantial enough to account for the behaviorally measured changes. Our recordings in V1 are as yet quite preliminary, but we expect to find a greater degree of maturation in V1 than we found at the level of the LGN. In addition to these studies, we have begun to measure the development of sensitivity to visual motion in primates. We plan to study the maturation of visual motion processing areas in the cortex to understand the maturational processes that underlie visual motion processing in infants.
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11 |
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4 |
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257 |
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365 |
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116 |
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540 |
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867 |
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466 |
Balakrishnan, Ashwini; Goodpaster, Tracy; Randolph-Habecker, Julie et al. (2017) Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues. Clin Cancer Res 23:3061-3071 |
Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2017) Asymmetric Dichoptic Masking in Visual Cortex of Amblyopic Macaque Monkeys. J Neurosci 37:8734-8741 |
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