This project is intended to design a model of pediatric AIDS, by mucosal inoculation of neonates with HIV-2287. One of the three macaques assigned to the project had been inoculated with 104 TCID of HIV-2287, had become infected, and developed AIDS (as defined by depletion of the CD4+ cell population from the peripheral blood) prior to this reporting period. However, this animal remained in apparent good health until the time of elective euthanasia, at which time a complete necropsy and histopathologic examination were done. Another of the macaques, a juvenile, was orally inoculated with HIV-2287 as a control animal for the neonates. This animal, although confirmed to be infected, did not show any other signs of disease, such as CD4+ depletion. The third macaque, inoculated orally as a neonate, has also become infected and has developed AIDS. This project has shown that M. nemestrina can be used as model of pediatric AIDS, and that infection by oral administration o f vi rus requires a high dose of virus, as compared with intravenous inoculation. FUNDING NIH grant RR00166.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
3P51RR000166-38S1
Application #
6219666
Study Section
Project Start
1999-05-01
Project End
2000-04-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
38
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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