The goal of this research is to understand the structure and function of ganglion cells-the output neurons-in macaque retina. Certain cells in the retina-the photoreceptors-are stimulated by long-, medium-, or short-wavelength light. The photoreceptors pass information to bipolar cells, which in turn relay to ganglion cells, which then output to visual centers of the brain. There are also cells within the retina-horizontal and amacrine-that """"""""hook up"""""""" to these circuits and share information with other cells within the retina. Some monkey species, like humans, share color vision based on three primaries-red, green and blue-which feed into two color-opponent channels in the brain. Our experiments are directed at determining which combinations of cell types are responsible for coding information about blue/yellow and red/green channels. We use intracellular recording and imaging in a unique preparation of living retina, combined with a three-color light, to test sensiti vity and c onnectivity of individual cells. FUNDING NIH grants RR00166, EY09625, EY06678, and EY03221. Peterson, B. and Dacey, D.M. Morphology of wide-field, monostratified ganglion cells of the human retina. Invest. Ophthal. Vis. Sci., Suppl. 39 S563, 1998 (abstract). Verweji, J., Dacey, D.M., and Buck, S.L.Receptive field size, sensitivity and dynamics of rod signals in macaque HI horizontal cells. Invest. Ophthal. Vis. Sci., Suppl. 39 S209, 1998 (abstract). Smith, V.C., Dacey, D.M., Lee, B.B., and Pokorny, J. Time dependent adaptation in primate horizontal cells. Invest. Ophthal. Vis. Sci., Suppl. 39 S209, 1998 (abstract). Lee, B.B., Dacey, D.M., Smith, V.C., and Pokorny, J. Spatial independence of adaptation in primate outer retina. Invest. Ophthal. Vis. Sci., Suppl. 39:S210, 1998 (abstract). [This project was also reported in the Neuroscience Core section.]
| Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11 |
| Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4 |
| Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257 |
| Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365 |
| Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116 |
| Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540 |
| Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867 |
| Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466 |
| Balakrishnan, Ashwini; Goodpaster, Tracy; Randolph-Habecker, Julie et al. (2017) Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues. Clin Cancer Res 23:3061-3071 |
| Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2017) Asymmetric Dichoptic Masking in Visual Cortex of Amblyopic Macaque Monkeys. J Neurosci 37:8734-8741 |
Showing the most recent 10 out of 320 publications
