This is a pilot study designed to explore the feasibility of training nonhuman primates to use a computerized """"""""joystick"""""""" testing apparatus. Animals will test various software programs designed to detect behavioral deficits seen in conjunction with SIV/HIV infection. This same testing protocol, with slight modifications, can also be used to test behavioral anomalies associated with practically any other factor (toxic, genetic, etc.) that is known to cause behavioral sequelae. Computerized testing is a powerful tool that can detect many aspects of performance deficits. It is totally noninvasive and the animals seem to enjoy performing the tasks. Therefore, data from this pilot project can also be used to design tasks to provide environmental enrichment to singly housed animals. During this last year the computerized joystick testing station was constructed and pilot testing was done. Modifications and adjustments were made to the original apparatus, including addition of an auditory reinforcement when the task is successfully completed and incorporation of a more sensitive and easily manipulable joystick. It has been determined that infant macaques as young as three months of age will interact with the joystick and monitor to obtain flavored reward pellets. Software that will administer learning and discrimination tests is now being piloted with infant macaques. FUNDING NIH grant RR00166.
| Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11 |
| Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4 |
| Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257 |
| Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365 |
| Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116 |
| Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540 |
| Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867 |
| Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466 |
| Balakrishnan, Ashwini; Goodpaster, Tracy; Randolph-Habecker, Julie et al. (2017) Analysis of ROR1 Protein Expression in Human Cancer and Normal Tissues. Clin Cancer Res 23:3061-3071 |
| Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2017) Asymmetric Dichoptic Masking in Visual Cortex of Amblyopic Macaque Monkeys. J Neurosci 37:8734-8741 |
Showing the most recent 10 out of 320 publications
