This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.During the past year, the IPRL has continued to focus on the development of a learning and memory test battery using a computerized, touch screen testing system. The IPRL has made significant contributions in the development of computer-based software tools for behavioral data collection. Under the direction of Dr. James Ha, IPRL Data Supervisor, new EVENT programs for Palm Pilots have been developed for observational data collection. In addition to being fully integrated into the IPRL, the Palm EVENT programs initially developed for use with infant monkeys have been adapted by Dr. Ha to study behavior in many animal species. Drs. Burbacher and Grant have continued to consult with Dr. Jim Phillips and Dr. Avery Weiss from Children's Hospital and Regional Medical Center and the Dept of Otolaryngology to develop noninvasive procedures to study the development of oculomotor function in infant primates. In parallel, Drs. Anita Hendrickson and Farrell Robinson are collecting anatomical data on the development of structures thought to be responsible for eye movement control, notably the infant primate cerebellum. To date, Drs. Phillips and Weiss have collected data on the development of eye movements in response to optokinetic stimuli in 16 infant monkeys and data on smooth pursuit in 4 infant monkeys. They are currently collecting data in human infants for direct comparison. In addition, data on smooth pursuit and vestibular ocular reflex development in nonhuman primate infants are now being gathered. IPRL staff is continuing to offer services to the Reproductive Biology program and provide assistance with ultrasound imaging and embryo transfers. Finally, the IPRL studies conducted in the laboratory since May, 2006 provided opportunities for training 11 undergraduate students since May 2006. This program has been highly successful in meeting one of the major goals of the University, providing quality undergraduate training in research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000166-46
Application #
7562710
Study Section
Special Emphasis Panel (ZRR1-CM-8 (02))
Project Start
2007-07-05
Project End
2008-04-30
Budget Start
2007-07-05
Budget End
2008-04-30
Support Year
46
Fiscal Year
2007
Total Cost
$148,249
Indirect Cost
Name
University of Washington
Department
Type
Other Domestic Higher Education
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
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Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
McAdams, Ryan M; McPherson, Ronald J; Kapur, Raj P et al. (2017) Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates. Dev Neurosci 39:107-123

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