This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Deep brain stimulation (DBS) in the internal globus pallidus (GPi) or subthalamic nucleus (STN) is a treatment used to reduce symptoms of Parkinson's disease. The mechanism by which DBS works is not known, and we have investigated it by stimulating in GPi or STN while we recorded the activity of target thalamic neurons in normal and unilateral MPTP-treated monkeys. We also have examined the effect on functional metabolic measures (PET measurement of FDG) when inhibitory synapses are activated in the thalamus, and we have continued our evaluation of the effects of chronic administration of rotenone to monkeys.
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