This grant is submitted, requesting 5 years of funding support for continuing operation of the Washington? National Primate Research Center at the University of Washington (WaNPRC). The major goal of this grant? proposal is to support a broad-based research resources program, providing biomedical scientists the? opportunity to conduct research using nonhuman primate (NHP) models for human health-related and NHP? biologic issues. This goal will be attained through support for scientific intellectual resources, administration,? animal support resources, facilities, and operations. Support is requested for translational and pre-clinical? resource support in AIDS-related research, Neuroscience, Functional Genomics and Infectious Disease,? Developmental and Reproductive Biology, and International Programs (Research Cores). New research? resource initiatives will develop novel NHP models as well as expanded related research resources,? including additional new core scientists. Support for pilot and colony health-related studies is requested to? provide new, innovative research directions and better characterization of the NHP resource. The WaNPRC? will focus on effective, efficient access to Center research resources, with particular emphasis placed on? support for affiliate research activities. This proposal also includes support for a broad program of animal? care and technical support for breeding, housing, and research activities (Research Resources Division),? including both domestic and international sites of operation. Administrative support is also requested to? insure appropriate management of Center finances and operations, focusing on improved efficiency and? effective support for research activities. Support is requested for WaNPRC breeding colonies located in? Seattle, the Tulane NPRC, the New Iberia Research Center, and internationally in Tinjil Island, Indonesia.? All primates housed in WaNPRC facilities are housed and cared for under conditions that meet or exceed? NIH standards as stated in the Guide for the Care and Use of Laboratory Animals, Institute for Laboratory? Animal Resources (ILAR) recommendations, and the Association for Assessment and Accreditation of? Laboratory Animal Care, International (AAALAC) accreditation standards for NHPs. All lentivirus-infected? primates are housed in ABSL2/3 containment facilities with appropriate biosafety procedures. The University? of Washington, including the WaNPRC, is fully accredited by AAALAC International.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000166-47
Application #
7463712
Study Section
Special Emphasis Panel (ZRR1-CM-8 (02))
Program Officer
Watson, Harold L
Project Start
1997-06-10
Project End
2012-04-30
Budget Start
2008-05-01
Budget End
2009-04-30
Support Year
47
Fiscal Year
2008
Total Cost
$12,480,373
Indirect Cost
Name
University of Washington
Department
Type
Other Domestic Higher Education
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Pham, Amelie; Carrasco, Marisa; Kiorpes, Lynne (2018) Endogenous attention improves perception in amblyopic macaques. J Vis 18:11
Zanos, Stavros; Rembado, Irene; Chen, Daofen et al. (2018) Phase-Locked Stimulation during Cortical Beta Oscillations Produces Bidirectional Synaptic Plasticity in Awake Monkeys. Curr Biol 28:2515-2526.e4
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Shushruth, S; Mazurek, Mark; Shadlen, Michael N (2018) Comparison of Decision-Related Signals in Sensory and Motor Preparatory Responses of Neurons in Area LIP. J Neurosci 38:6350-6365
Raghanti, Mary Ann; Edler, Melissa K; Stephenson, Alexa R et al. (2018) A neurochemical hypothesis for the origin of hominids. Proc Natl Acad Sci U S A 115:E1108-E1116
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Oleskiw, Timothy D; Nowack, Amy; Pasupathy, Anitha (2018) Joint coding of shape and blur in area V4. Nat Commun 9:466
Eberle, R; Jones-Engel, L (2017) Understanding Primate Herpesviruses. J Emerg Dis Virol 3:
McAdams, Ryan M; McPherson, Ronald J; Kapur, Raj P et al. (2017) Focal Brain Injury Associated with a Model of Severe Hypoxic-Ischemic Encephalopathy in Nonhuman Primates. Dev Neurosci 39:107-123

Showing the most recent 10 out of 320 publications