To determine if atropine can eliminate the age-related decline in outflow facility in rhesus monkeys RESULTS We determined in rhesus monkeys ages 4-24 years, that baseline outflow facility decreases by 0.0160q0.0059 l/min/mmHg/yr. The average baseline facility was ~50% higher in the youngest (ages 4-=10 years) compared to the oldest (ages 21-25 yrs). Atropine decreased facility by 25% compared to baseline in the youngest monkeys but not at all in the oldest animals. The inability of atropine to completely eliminate the age-related facility decline indicates the presence of atropine-independent, facility relevant age-dependent changes in the trabecular meshwork itself such as loss of cells or build-up of extracellular material. Similar changes could contribute to the development of elevated intraocular pressure and glaucoma in aging humans. FUTURE DIRECTIONS We will study the age-dependence of uveoscleral outflow in rhesus; another fluid outflow pathway which may be compromised during the aging process. KEY WORDS atropine, trabecular meshwork, extracellular material, glaucoma

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000167-38
Application #
6277704
Study Section
Project Start
1998-05-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
38
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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