Huntington's disease (HD) and Parkinson's disease (PD) are neurodegenerative diseases. The neuropathological, neurochemical and behavioral hallmarks of HD can be replicated in the non-human primate by stereotaxic excitotoxic lesions of the caudate-putamen (Isacson et al. 1989). In a MPTP chronic lesion model of PD, we are currently pharmacologically testing drugs for therapeutic effects in combination with transplantation of fetal neurons. Behavioral testing of the HD and PD models is therefore of utmost importance for developing a neurobiological basis for new treatments of neurodegenerative disease. The HD model determines the neurological basis for basal ganglia dependent dyskinesia. This year we will continue our lesion and transplantations studies in combination with PET and MRI studies to develop a therapy against the symptoms seen in HD and PD.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000168-37
Application #
6277831
Study Section
Project Start
1998-05-01
Project End
1999-04-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
37
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
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